Edelfosine induces an apoptotic process in Leishmania infantum that is regulated by the ectopic expression of Bcl-XL and Hrk |
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| Authors: | Alzate Juan Fernando Arias Andrés Mollinedo Faustino Rico Eva de la Iglesia-Vicente Janis Jiménez-Ruiz Antonio |
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| Institution: | Juan Fernando Alzate, Andrés Arias, Faustino Mollinedo, Eva Rico, Janis de la Iglesia-Vicente, and Antonio Jiménez-Ruiz |
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| Abstract: | The alkyl-lysophospholipids edelfosine and miltefosine induce apoptosis in Leishmania infantum promastigotes. The finding that edelfosine-induced cell death can be regulated by the ectopic expression of the antiapoptotic and proapoptotic members of the Bcl-2 family of proteins Bcl-XL and Hrk suggests that this process is similar to apoptosis in eukaryotic cells. |
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