枳术党参颗粒肠推进和镇吐作用的实验研究

目的 观察枳术党参颗粒的肠推进和镇吐作用. 方法 采用阿托品、多巴胺以及肾上腺素诱导肠功能低下小鼠模型,研究枳术党参颗粒的肠推进作用;通过硫酸铜和顺铂诱导的家鸽呕吐模型,观察枳术党参颗粒的镇吐作用. 结果枳术党参颗粒20 g/kg 1次给药能提高由阿托品抑制的小鼠肠推进活动,枳术党参颗粒10、20 g/kg 3次预防给药能提高多巴胺和肾上腺素抑制的小鼠肠推进活动;枳术党参颗粒16 g/kg 1次给药能减少硫酸铜所致家鸽的呕吐次数,枳术党参颗粒(4、8、16 g/kg)3次给药对顺铂所致家鸽的呕吐无明显作用.结论 枳术党参颗粒有明显的促进小鼠肠排空作用,对外周呕吐有一定的镇吐作用.

Experimental study of zhizhu dangshen granules on intestinal propulsive function and antemtic effect

Objective To study the effects of zhizhu dangshen granules on intestinal propulsive function and an-temtic effect in animals. Methods The models of intestinal dysfunction induced by atropine, dopamine and epi-nephrine in mice were used to study gastrointestinal propulsive function. The models of vomit induced by copper sulfate and cisplatin in pigeon were used to study antemtic effect. Results A single administration of Zhizhu dang-shen granules (20 g/kg) could alleviate inhibition of intestinal propulsive function induced by atropine in mice. Three preventive administration of Zhizhu dangshen granules (10 g/kg and 20 g/kg) could improve the inhibition of intestinal propulsive function induced by dopamine and epinephrine in mice. A single administration of Zhizhu dangshen granules (16 g/kg) could reduce the vomitive times induced by copper sulfate in pigeon. Three preven-tive administration of Zhizhu dangshen granules (4 g/kg, 8 g/kg and 16 g/kg) had no effect on vomit induced by cisplatin in pigeon. Conclusion Zhizhu dangshen granules significantly increases intestinal propulsive function. It also has certain antiemetic effect on peripheral vomit.