Strategy of surgical treatment of children with extensive deep burns using cultured allofibroblasts

Thirty-one children aged 1–14 years with thermal burns of the third-fourth degree on 40–85% body surface were treated using cultured human skin allofibroblasts. Combination of early surgical necrectomy with transplantation of cell culture and subsequent autodermoplasty with skin flaps with a high perforation coefficient proved to be highly effective in burned patients with deficit of donot skin. Indications for the use of this orginal method for skin repair after critical and supercritical burns are defined. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 3, pp. 333–336, March, 2000