| Twist在胃癌黏膜组织的表达及在上皮间质转化中的作用 |
| |
| 引用本文： | 冯美燕,宁晓明,刘婷,耿敬姝.Twist在胃癌黏膜组织的表达及在上皮间质转化中的作用[J].现代肿瘤医学,2008,16(11). |
| |
| 作者姓名： | 冯美燕 宁晓明 刘婷 耿敬姝 |
| |
| 作者单位： | 哈尔滨医科大学附属肿瘤医院病理科,黑龙江,哈尔滨,150081 |
| |
| 基金项目： | 黑龙江省自然科学基金，哈医大附属肿瘤医院基金 |
| |
| 摘 要： | 目的:观察上皮间质转化因子Twist在胃癌中的表达情况以及与胃癌恶性生物学行为的相关性。方法:采用免疫组化SP法检测59例胃癌组织中Twist,上皮源性标记物E-cadherin,间叶源性标记物Vimentin的表达,并分析与各临床病理因素之间的关系。结果:59例胃癌组织中Twist阳性表达率为74.6%(44/59),29例观察到E-cadherin表达的降低,同时7例观察到Vimentin表达上调。Twist的表达与淋巴结转移密切相关(P<0.05);而且Twist表达与E-cadherin表达降低(P<0.05)和Vimentin的表达上调(P<0.05)之间都存在相关性。结论:Twist可能通过调控上皮间质转化从而在胃癌的侵袭转移过程中发挥作用。
|
| 关 键 词： | 胃癌 Twist E-cadherin 上皮间质转化 转移 |
Expression of Twist in gastric cancer and its role in epithelial-mesenchymal transition |
| |
| FENG Mei-yan,NING Xiao-ming,LIU Ting,GENG Jing-shu.Expression of Twist in gastric cancer and its role in epithelial-mesenchymal transition[J].Journal of Modern Oncology,2008,16(11). |
| |
| Authors: | FENG Mei-yan NING Xiao-ming LIU Ting GENG Jing-shu |
| |
| Abstract: | Objective:To investigate the expression of epithelial-mesenchymal transition(EMT) related markers Twist in gastric carcinoma tissues and its relation with the malignant features.Methods:The expression of Twist,E-cadherin and Vimentin proteins in 59 cases of gastric cancer tissues was detected by using immunohistochemistry and compared with clinicopathological data.Results:Twist was detected in 44 cases(74.6%) of gastric cancer.The expression of E-cadherin was reduced in 29 cases and Vimentin was up-regulated in 7 cases of gastric carcinoma.The expression of Twist was significantly related with the lymph node metastasis(P<0.05),the reduced expression of E-cadherin(P<0.05) and the increased expression of Vimentin(P<0.05).Conclusion:The expression of Twist in gastric cancer may accelerate invasion of gastric cancer through EMT. |
| |
| Keywords: | gastric cancer Twist E-cadherin EMT metastasis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
