清知源软胶囊对高脂血症大鼠血脂及抗氧化活性的影响

目的：研究清知源软胶囊对大鼠血脂的调节作用以及抗氧化活性的影响。方法：采用50只健康Wistar大鼠按照体重和血脂水平随机分成5组。分别接受正常饲料、高脂模型对照、高脂饲料加入清知源软胶囊（高、低剂量分别为20、5mg／kg）、阳性药对照灌胃处理。3周后取血测定血脂和抗氧化酶的含量。结果：与高脂模型组大鼠相比，清知源软胶囊组可以显著降低大鼠血清TC、TG、LDL．C、MDA含量，升高血清HDL-C含量，使血清和肝组织超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH—Px）活性上升，丙二醛（MDA）含量降低（P〈0．05）。结论：清知源软胶囊可以明显地调节血脂，提高抗氧化能力，抑制脂质过氧化．

Effects of Qingzhiyuan soft capsule on blood lipid and antioxidantion in hyperlip-idemia rats

Objective: To study the effects of Qingzhiyuan soft capsule(QZY) on blood lipid and antioxidant activity in hyperlipi-demia rats. Methods: Fifty Wister rats were randomly divided into five groups according to body weight and serum cholesterol levels. They were fed one of five diets, a reference diet, a high fat supplemented diet and a high fat supplemented with 20mg/kg, 5mg/kg QZY, a positive diets. After three weeks, blood lipid and antioxidant activity were determined respectively. Results: Compared with model, QZY could reduced the serum TC, TG, LDL-C concentration, increased SOD and GSH-Px activities, decreased MDA level significantly(P <0. 05). Conclusion: QZY might play an important role in preventing hyperlipidemia through its antioxidative effect.