磁共振导引下氩氦刀冷冻消融联合化疗治疗老年晚期肺癌的临床研究

目的 探讨磁共振导引下氩氦刀冷冻消融联合化疗治疗老年晚期肺癌的效果.方法 选择2012年6月—2015年6月收治的老年晚期肺癌患者215例.按治疗方法分为观察组112例和对照组113例,对照组采用单纯化疗,观察组在对照组基础上采用磁共振导引下氩氦刀冷冻消融.观察两组近期疗效、T淋巴细胞亚群水平变化情况及生存时间.结果 观察组肿瘤控制率、临床受益率均高于对照组(P<0.05).治疗后,两组CD3+、CD4+和CD4+/CD8+水平均高于治疗前,CD8+低于治疗前(P<0.05);且观察组CD3+、CD4+和CD4+/CD8+水平高于对照组,CD8+低于对照组(P<0.05).观察组生存时间长于对照组(P<0.05).结论 磁共振导引下氩氦刀冷冻消融联合化疗治疗老年晚期肺癌能提高临床效果,延长生存时间,提高机体免疫力.

MRI-guided Argon-helium Cryoablation Combined with Chemotherapy in Treatment of Elderly Patients with Advanced Lung Cancer

Objective To investigate magnetic resonance imaging ( MRI )-guided argon-helium cryoablation combined with chemotherapy in treatment of elderly patients with advanced lung cancer. Methods A total of 215 elderly patients with advanced lung cancer were admitted during June 2012 and June 2015 were divided into observation group (n=112) and control group (n =113) according to treatment methods. Control group received chemotherapy only, while observation group was treated with MRI-guided argon-helium cryoablation on the basis of treatment for control group. The short-term efficacy, changes of T lymphocyte subsets levels and survival time were observed in two groups. Results Tumor control and clinical benefit rates in observation group were significantly higher than those in control group (P<0. 05). After treatment, CD3+, CD4+ and CD4+/CD8+ levels were significantly higher, while CD8+ levels were significantly lower than those before treatment in two groups (P<0. 05);in observation group, the CD3+, CD4+ and CD4+/CD8+ levels were significantly higher, while CD8+ level was significantly lower than those in control group (P<0. 05). Survival time in observation group was significantly longer than that in control group (P<0. 05). Conclu-sion MRI-guided argon-helium cryoablation combined with chemotherapy in treatment of elderly patients with advanced lung cancer can improve clinical effect, prolong survival time and enhance the immunity.