冠脉病变严重程度与血清hs-CRP水平的相关性研究

目的　研究血清高敏C反应蛋白 (high sensitivityC reactiveprotein ,hs CRP)与冠心病患者冠状动脉病变狭窄程度、病变支数、稳定情况的相关性 ,探讨hs CRP对冠状动脉病变严重程度的预测价值。方法　冠状动脉造影确诊冠心病的 5 7例患者 ,其中稳定型心绞痛 (SAP) 2 6例 ,不稳定型心绞痛(UAP) 31例 ,对冠脉造影结果采用Gensini积分系统定量评定冠脉血管病变狭窄严重程度 ,以冠脉造影正常者 (19例 )为对照组 ,分析血清hs CRP与冠状动脉病变狭窄程度、病变支数、稳定情况的相关性。结果　冠心病患者冠状动脉病变狭窄程度Gensini积分、冠脉病变支数与血清hs CRP水平均呈正相关 (相关系数分别为r =0 .379,P =0 .0 1;r =0 .2 94 ,P <0 .0 5 )。冠心病临床分组不稳定型心绞痛组与稳定型心绞痛组及正常对照组之间血清hs CRP水平组间差异有非常显著意义 (P <0 .0 1) ;多支病变与单支病变及对照组血清hs CRP水平比较差异有显著意义 (P <0 .0 5 )。结论　血清hs CRP水平与冠心病患者冠状动脉病变狭窄程度、病变支数及稳定性密切相关 ,有助于临床评估冠心病患者冠状动脉病变严重程度。

Relationship between serum high-sensitivity C-reactive protein and severity of coronary artery lesion in patients with coronary heart disease

Objective To investigate the relationship betw een serum high-sensitivity C-reactive protein(hs-CRP) and the severity of ste nosis, stenosis number and stability of coronary artery in patients with corona ry heart disease (CHD),and to explore its predictive value for the stenosis of c oronary artery in patients with CHD. Methods Fifty-seven patie nts diagnosed as CHD by coronary angiography,twenty-six patients with stable an gina pectoris (SAP group)and thirty-one patients with unstable angina pectoris (UAP group)were enrolled in the study. The severity scale of coronary artery ste nosis was quantitatively assessed according to coronary angiography by Gensini s core. There were 19 normal subjects who underwent coronary angiography and prove d to not be CHD (control group). The correlation between hs-CRP and the severit y of stenosis, stenosis number, stability of coronary artery in patients with C HD was analyzed.Results The Gensini score of CHD stenosis and t he number of stenosis coronary artery were correlated positively w ith hs-CRP (r=0.379,P=0.01;r=0.294,P<0.05,respectively).There were significant differences in hs-CRP among SAP group, UAP group and control grou p(P<0.01). Among single ramus group and multitude ramus group there were al so significant differences in hs-CRP (P<0.05). Conclusion The hs-CRP is closely related to the severity of stenosis, stenosis number, st ability of coronary artery in CHD patients,which will be helpful to evaluating t he severity of coronary artery lesion in patient swith CHD