Human papillomavirus type 16 viral load is higher in human immunodeficiency virus-seropositive women with high-grade squamous intraepithelial lesions than in those with normal cytology smears |
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| Authors: | Lefevre Jonas,Hankins Catherine,Money Deborah,Rachlis Anita,Pourreaux Karina,Coutlée François Canadian Women's HIV Study Group |
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| Affiliation: | Laboratoire de Virologie Moléculaire, Centre de Recherche du Centre Hospitalier de l'Université de Montréal and Département de Microbiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada. |
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| Abstract: | Human papillomavirus type 16 (HPV-16) viral load in cervicovaginal lavage samples collected from 66 human immunodeficiency virus-seropositive women was inversely correlated with blood CD4 count (P = 0.002). HPV-16 viral load was 81-fold higher in women with cervical smears suggestive of high-grade lesions (median, 4,425,883 copies/ micro g of DNA) than in women with normal smears (median, 54,576), controlling for age (P = 0.006). |
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