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Ursodeoxycholic acid induces glutathione synthesis through activation of PI3K/Akt pathway in HepG2 cells |
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| Authors: | Sakiko Arisawa Natsumi Kameyama Ai Hattori Yasuaki Tatsumi Motoyoshi Yano Yoshiaki Katano Kenji Takagi |
| Affiliation: | a Department of Medical Technology, Nagoya University School of Health Sciences, Nagoya, Japan b Department of Medicine, Aichi Gakuin University School of Pharmacy, Nagoya, Japan c Department of Internal Medicine, Yokkaichi City Hospital, Yokkaichi, Japan d Division of Gastroenterology, Department of Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan |
| Abstract: | |
| Keywords: | ROS, reactive oxygen species UDCA, ursodeoxycholic acid CHC, chronic hepatitis C ALT, alanine aminotransferase PI3K, phosphatidylinositol 3-kinase Nrf2, nuclear factor-E2-related factor-2 GCL, glutamine-cysteine ligase GSHS, GSH synthetase CDCFH, dichlorodihydrofluorescein mBCl, monochlorobimane PCR, polymerase chain reaction ERK, extracellular signal-regulated protein kinase MAPK, mitogene-activated protein kinase GAPDH, glycerine aldehyde dehydrogenase |
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