丙型肝炎病毒感染致糖代谢异常的相关机制研究进展 |
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引用本文: | 康姚洁[综述] 王煊[审校]. 丙型肝炎病毒感染致糖代谢异常的相关机制研究进展[J]. 实用肝脏病杂志, 2014, 0(1): 102-105 |
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作者姓名: | 康姚洁[综述] 王煊[审校] |
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作者单位: | 解放军第302医院内分泌科,北京市100038 |
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摘 要: | 丙型肝炎病毒感染者糖代谢异常的发病率有不同程度的升高。除了肝源性糖尿病共有的发病机制外,胰岛β细胞功能的减低和胰岛素抵抗(IR)在丙型肝炎病毒感染者糖代谢异常的发病机制中起着重要作用。但IR可能更为重要,而肝脂肪变性、肿瘤坏死因子-α过表达、脂联素水平下降、细胞因子信号抑制因子合成以及铁代谢异常等都可能参与了IR的形成。
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关 键 词: | 慢性丙型肝炎 糖尿病 胰岛素抵抗 |
Progress in mechanisms of abnormal glucose metabolism in patients with hepatitis C virus infection |
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Affiliation: | Kang Yaojie, Wang Xuan (Deportment of Endocrinology, 302nd Hospital, Beijing 100038, China) |
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Abstract: | The morbidity of abnormal glucose metabolism in patients with hepatitis C infection increases gradually. In addition to the common pathogenesis similar to hepatogenous diabetes,malfunciton in pancreaticβ-cell and insulin resistance (IR) play important roles in the pathogenesis of abnormal glucose metabolism in pa-tients with hepatitis C virus infection. IR may be more important,and hepatic steatosis, tumor necrosis factor-αoverexpression,decreased adiponectin, abnormality in synthesis of cytokine signaling inhibitory factors and in iron metabolism may all be involved in IR. |
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Keywords: | 核因子-κB Choronic hepatitis C Diabetes Insuline resitence Nuclear factor-κB |
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