近10年非酒精性脂肪性肝病研究热点共词聚类分析

目的了解中国近10年在非酒精性脂肪性肝病（NAFLD）领域的研究热点和主题结构。方法以2014年2月为检索节点,对＂中国科技引文数据库（CSCD）＂中2004年1月～2013年12月所收录的有关NAFLD研究文献中的关键词作为研究对象,采用词频分析、因子分析和共词聚类分析等方法,应用Excel 2010和SPSS17.0统计软件对这些关键词进行统计分析。结果共检索到标注关键词的NAFLD相关文献852篇,截取的40个高频关键词涵盖全部相关论文数的70.2%;经共词聚类分析归纳出有关NAFLD研究中的9个研究热点：胰岛素增敏药物、超声检查、流行病学及危险因素、动物模型、发病机制及中医药疗法、胰岛素抵抗、中医药研究、基因水平和临床诊治研究。结论本文归纳出的9个研究热点涵盖了近10年在NAFLD研究领域的中文文献,了解它们的进展有助于相关研究的扩展。

Chinese science citation database based co-words clustered analysis on research hotspots in non-alcoholic fatty liver diseases in China during the past decade

Objective To explore the research hotspots and subject structure of non-alcoholic fatty liver diseases（NAFLD） in China in the past decade. Methods The key words of articles in NAFLD field were retrieved in Chinese science citation database（CSCD） from January 2004 to December 2013. Word-frequency analysis,factor analysis and co-words clustered analysis were applied and statistic analysis was performed using excel 2010 and SPSS17.0. Results Eight hundred and fifty-two articles in presence of keywords about NAFLD were included and 40 high-frequency words were selected,which accounted for 70.2% of all relevant papers. The co-word clustered analysis showed that there were 9 hot subjects about NAFLD during last 10 years including insulin-sensitizing drugs,ultrasonography,epidemiology and risk factors,animal models,pathogenesis and traditional Chinese medicine,insulin resistance,Chinese medicine research,as well as gene and clinical treatment studies.Conclusions The co-word clustered analysis of research hotspots helps to understand the developmental of NAFLD in China.