普通人群肝脏受控衰减参数的多元回归分析

目的：探讨影响普通人群肝脏受控衰减参数的相关因素。方法使用 FibroScan○R-520诊断仪检测208例健康体检者肝脏受控衰减参数（CAP 值），同时获取受试者的主要生化指标和性别、年龄、体质量指数、腰高比、腰臀比，对其进行多元线性回归分析和偏最小二乘回归分析，建立回归方程。结果多元线性回归分析显示， CAP 值与体质量指数、腰臀比和年龄呈显著性相关，其标准回归系数分别为：体质量指数，β=0.2538，P=0.0007；腰臀比，β=0.1781，P=0.0158；年龄，β=0.1935，P=0.0022；通过多元回归分析和偏最小二乘回归建立的模型分别为：CAP=-137.70＋9.40×215;甘油三脂＋5.40×215;体质量指数＋176.34×215;腰臀比＋1.60×215;年龄，改良的 CAP=-135.23＋11.57×215;甘油三脂＋4.82×215;体质量指数＋212.81×215;腰臀比＋1.12×215;年龄。结论普通人群 CAP 正常值范围受体质量指数、腰臀比和年龄的影响，改良的回归模型能更好地反映肝脏 CAP 值。

Multivariable regression analysis of controlled attenuation parameter of liver by FibroScan in healthy in-dividuals

Objective To explore the related factors of controlled attenuation parameter （CAP） of liver ob-tained by FibroScan examination in healthy individuals. Methods The CAP was obtained by FibroScan in 208 healthy persons,and the main biochemical indexes,gender,age,body mass index （BMI）,waist-hip ratio （WHR） and waist-height ratio were collected at the same time,and the relationship between CAP value and these common indi-cators was analyzed. Results Multiple linear regression analysis showed that CAP value was significantly correlated with BMI,WHR and age （for BMI,β=0.280,P=0.0002;for WHR,β=0.206,P=0.0059;for age,β=0.192,P=0.0022）;And the regression equation established after multiple linear regression analysis and partial least squares regression were CAP=-137.70＋9.40＊TG＋5.40＊BMI＋176.34＊WHR＋1.60＊age and the adjusted CAP=-92.11＋10.67＊TG- 10.25＊HDL＋4.45＊BMI＋196.25＊WHR＋1.03＊age. Conclusions The range of CAP value is affected by BMI,WHR,and age in the general population,the adjusted regression equation is more better to predict the CAP value of the liver.