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64层螺旋CT门静脉造影对肝硬化患者肝功能分级和食管静脉曲张破裂出血的预测价值
引用本文:刘文娜,郝婷婷,王剑,宁涛,谢元元,冯义朝,戴光荣. 64层螺旋CT门静脉造影对肝硬化患者肝功能分级和食管静脉曲张破裂出血的预测价值[J]. 实用肝脏病杂志, 2014, 0(3): 283-286
作者姓名:刘文娜  郝婷婷  王剑  宁涛  谢元元  冯义朝  戴光荣
作者单位:[1]延安大学附属医院消化内科二病区,陕西省延安市716000 [2]延安大学附属医院CT室,陕西省延安市716000 [3]延安大学附属医院普外科二病区,陕西省延安市716000
基金项目:延安大学附属医院研究生创新基金项目(编号:10YJ11)
摘    要:目的:评价64层螺旋 CT 门静脉造影在肝硬化患者肝功能分级和食管静脉曲张破裂出血(EVB)预测中的临床价值。方法使用64层螺旋 CT 对64例肝硬化患者(消化道出血组30例、非出血组34例)及36例正常对照人群门静脉主干(MPV)、脾静脉(SPV)、胃左静脉(LGV)、肝内门静脉左支(IHLPV)和肝内门静脉右支(IHRPV)进行测量;应用受试者工作特征曲线下面积(AUC)评价上述各指标预测 EVB 的价值。结果肝硬化患者 MPV、SPV、LGV、IHLPV 和 IHRPV 直径分别为(1.68±0.21)cm、(1.45±0.18)cm、(0.53±0.12)cm、(1.21±0.15)cm 和(1.26±0.22)cm,显著高于对照组[分别为(1.18±0.14)cm、(0.80±0.09)cm、(0.42±0.07)cm、(0.95±0.07)cm 和(0.96±0.11)cm,P<0.05];Child-Pugh C 级患者 MPV、SPV、LGV、IHLPV 和 IHRPV 直径分别为(2.01±0.20)cm、(1.57±0.10)cm、(0.59±0.11)cm、(1.36±0.09)cm 和(1.45±0.12)cm,显著高于 Child-Pugh A 级患者[分别为(1.68±0.15) cm、(1.35±0.13)cm、(0.48±0.09)cm、(1.11±0.13)cm 和(1.15±0.21)cm,P<0.05];消化道出血患者 MPV、SPV、LGV 和 IHLPV 直径分别为(1.78±0.16)cm、(1.54±0.20)cm、(0.62±0.10)cm 和(1.28±0.15)cm,显著高于非出血患者[分别为(1.60±0.21)cm、(1.36±0.13)cm、(0.45±0.06)cm 和(1.15±0.13)cm,P<0.05];出血患者 IHRPV 直径[(1.29±0.21)cm]与非出血患者[(1.25±0.23)cm]差异无统计学意义;LGV 的 AUC 为0.906。当 LGV>0.61 cm 时,预测 EVB 的敏感度为93.3%,特异度为58.8%。结论64层螺旋 CT 门静脉造影能够清晰显示肝硬化门静脉高压侧支循环血管情况,并对预测 EVB 具有一定的临床应用价值。

关 键 词:肝硬化  食管静脉曲张  64层螺旋CT  门静脉造影

Prediction of esophageal variceal bleeding with 64-slice spiral CT portography in cirrhotic patients
Affiliation:Liu Wenrm, Hao Tingting, Wang fian,et al.( Department of Gastroenterology,Affiliated Hospital, Yah' an University, Yon' an 716000 , Shaanxi Province, China)
Abstract:Objective To assess the clinical value of 64-slice spiral CT portography in prediction of esophageal variceal bleeding(EVB) in cirrhotic patients. Methods Sixty four patients with liver cirrhosis(30 cases with EVB, and 34 without) and 36 normal persons underwent 64-slice spiral CT portography and the diameters of the main portal vein (MPV),splenic vein (SPV),left gastric vein (LGV),intrahepatic left portal vein (IHLPV) and intrahepatic right portal vein(IHRPV) were measured; The ability of these indexes in prediction of EVB were evaluated by the area under the receiver operating characteristic (ROC) curves (AUC). Results The diameters of MPV,SPV,LGV,IHLPV and IHRPV in cirrhotic patients were (1.68±0.21) cm,(45±0.18) cm,(0.53±0.12) cm,(1.21±0.15) cm and(1.26±0.22) cm,respectively, significantly higher than those in the controls[(1.18±0.14) cm,(0.80 ±0.09) cm,(0.42 ±0.07) cm,(0.95 ±0.07) cm and (0.96 ±0.11) cm,respectively,P 〈0.05];The diameters of MPV,SPV,LGV,IHLPV and IHRPV in patients with Child-Pugh class C were(2.01±0.20)cm,(1.57± 0.10) cm,(0.59±0.11)cm,(1.36±0.09) cm and (1.45±0.12) cm,respectively,significantly higher than those in patients with Child-Pugh class A[(1.68±0.15)cm,(1.35±0.13)cm,(0.48±0.09)cm,(1.11±0.13)cm and(1.15±0.21) cm,respectively,P〈0.05];The diameters of MPV,SPV,LGV and IHLPV in EVB group were (1.78±0.16) cm,(1.54±0.20)cm,(0.62±0.10)cm and(1.28±0.15)cm,respectively,significantly higher than those in patients without EVB[(1.60±0.21)cm,(1.36±0.13)cm,(0.45±0.06)cm and(1.15±0.13)cm,respectively,P〈0.05];The diameter of IHRPV showed no difference between patients with EVB (1.29±0.21)cm and without EVB (1.25±0.23)cm;The AUC of LGV was 0.906,and the sensitivity and specificity in prediction of EVB were 93.3% and 58.8% , respectively when LGV was greater than 0.61 cm. Conclusion 64-slice spiral CT portal venography can not only clearly show the collateral vessels of portal hypertension in cirrhotic patients,but also has a certain value in prediction of EVB in clinical practice.
Keywords:Cirrhosis  Esophageal varices  64-slice spiral CT  Portography
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