健康体检成人FibroScan检测肝脏硬度值与受控衰减参数的相关分析

目的探讨普通人群肝脏硬度测量值（LSM）与受控衰减参数（CAP）之间的关联,为临床研究提供参考。方法在207例成功进行FibroScan检查的健康体检者,获取性别、年龄、体质量指数（BMI）和腰高比（WHtR）资料,分析其LSM和CAP的相关性。结果不同年龄人群LSM的差异无统计学意义,但在BMI≥24 kg/㎡的受试者,其LSM和CAP值分别为（4.60±1.15）kPa和（245.24±55.37）dB/m,均显著高于BMI〈24 kg/㎡的受试者[（4.25±1.23）kPa和（215.82±55.47）dB/m,P〈0.001];WHtR≥0.50的受试者LSM和CAP分别为（4.52±1.22）kPa和（247.04±57.78）dB/m,亦均高于WHtR〈0.50的受试者[（4.19±1.15）kPa和（204.65±52.25）dB/m,P〈0.05];男性受试者LSM和CAP值亦均高于女性受试者[（4.53±1.23）kPa和（4.11±1.08）dB/m对（4.11±1.08）kPa和（220.08±57.88）dB/m,P〈0.05];年龄≥50岁的受试者CAP值[（246.56±59.06）dB/m]高于年龄〈50岁的受试者[（222.88±56.60）dB/m];LSM与CAP值呈显著性正相关（r=0.26,P=0.0002）;进一步对各组人群分析发现,在BMI≥24 kg/㎡、WHtR〉0.50、男性受试者和年龄≥50岁的受试者中,LSM与CAP值呈显著性正相关（P〈0.05）,其中在BMI≥24 kg/㎡组人群,两者呈非常显著性正相关（r=0.37,P〈0.01）;通过相关分析发现,LSM和CAP均与BMI、WHtR和性别相关（P〈0.05）;通过偏相关分析发现,LSM与CAP参数之间呈显著性正相关（r=0.20,P=0.0045）;在体质量指数≥24 kg/㎡的超重或肥胖的受试者中,肝脏硬度值和受控衰减参数的相关性更强（r=0.37,P=0.0003）。结论普通人群LSM与CAP均受BMI、WHtR和性别的影响,并且两个参数之间表现出一定的正相关,其相关存在的确切原因有待于进一步研究。

A correlation of liver stiffness to controlled attenuation parameter in healthy individuals

Objective To explore the correlation between liver stiffness measurement（LSM） and controlled attenuation parameter（CAP） in the general population. Methods A correlation of LSM to CAP was conducted in a total of 207 participants who were successfully examined by FibroScan in a general health examination,and the data including gender,age,body mass index（BMI） and waist height radio（WHtR） were recorded. Results The LSM and CAP in overweight and obese participants（BMI≥24 kg/m^2） were higher than those in lean participants（BMI24 kg/m2） [（4.60±1.15）kPa vs.（4.25±1.23）kPa,P〈0.001 and（245.24±55.37） dB/m vs.（215.82±55.47） dB/m,P 0.001];participants with WHtR ≥0.50 had higher LSM and CAP as compared to those with WHtR 0.50[（4.52±1.22） kPa vs.（4.19±1.15） kPa,P〈0.05 and（247.04±57.78） dB/m vs.（204.65±52.25） dB/m,P〈0.05];male participants had higher LSM and CAP than in female[（4.53 ±1.23）kPa vs.（4.11 ±1.08） kPa,P 0.05 and（4.11±1.08） dB/m vs.（220.08±57.88） dB/m,P〈0.05];the CAP was higher in participants older than 50 years as compared to participants under 50 years[（246.56 ±59.06）dB/m vs.（222.88 ±56.60） dB/m,P 0.01],while the LSM in the two groups showed no difference（P〈0.05）;The LSM was significantly correlated with CAP in this cohort（r =0.26,P =0.0002）;Further analysis demonstrated that CAP was correlated with LSM in male,older than or equal to 50 years,BMI≥24 kg/m2 or WHtR≥0.50（P〈0.05） and the correlation was even more significant in individuals with BMI≥24 kg/m2（P〈0.01）;both LSM and CAP were correlated with gender,BMI and WHtR;partial correlation analysis revealed a weak positive correlation between CAP and LSM（r =0.20,P =0.0045） and the correlation was more obvious in overweight and obese participants（r=0.37,P=0.0003）. Conclusion Both LSM and CAP were affected by gender,BMI and WHtR in general population and there was a positive correlation between LSM and CAP.Further study is required