应用改良Simpson法评价肝豆状核变性患者胆囊收缩功能

应用心脏左室容量计算法（改良Simpson法）评价肝豆状核变性患者胆囊收缩功能。方法选择肝豆状核变性患者54例和正常人60例，分别于空腹和脂餐试验后在胆囊长轴切面应用改良Simpson法测量胆囊容积，计算胆囊排空率。结果在空腹状态下，肝豆状核变性患者与正常对照组胆囊容积分别为（27.31±6.90）ml和（25.63±4.72）ml，差异无统计学意义（P〉0.05）；在高脂餐后，肝豆状核变性患者胆囊容积为（10.31±4.61）ml，明显大于正常对照组（3.41±2.78）ml，P〈0.05]；餐后肝豆状核变性患者胆囊排空率为（54.85±12.12）%，显著低于正常对照组（73.48±7.60）%，P〈0.01]。结论采用改良Simpson法测量胆囊容积具有简单易行和重复性好的特点，有助于临床上评估肝豆状核变性患者的胆囊收缩功能。

Application of the modified Simpson method in evaluation of gallbladder contractility in patients with hepatolenticular degeneration

To evaluate the gallbladder contractility of patients with hepatolenticular de-generation （HLD） by cardiac left ventricular volume calculation method （modified Simpson method）. Methods The modified Simpson method was conducted at the long axis view to measure the gall-bladder volume of 104 subjects （54 with HLD and 60 normal persons） under fasting conditions and after the administration of lipoid-food,and the gallbladder emptying rates in two groups were calculat-ed and compared. Results Under the fasting state,there was no statistical difference in the volume of gallbladder between the patients with HLD （27.31±6.90） ml] and the healthy controls （25.63± 4.72） ml];after the conduction of lipoid-food test,the gallbladder volume in patients with HLD was （10.31 ±4.61）ml,significantly bigger than in the controls （3.41 ±2.78）ml,P〈0.05],while the gall-bladder emptying rate in patients with HLD （54.85±12.12）%] was significantly lower than that in the controls （73.48±7.60）%,P〈0.01]. Conclusions The modified Simpson method is easy to perform and of good repeatability in measurement of gallbladder volume and is helpful in evaluation of gall-bladder contractility in patients with HLD.