Hemoconcentration during a prolonged stress task: Associations with hemodynamic reactivity and microvascular permeability

This study explored the association between stress-induced hemoconcentration and plasma colloid osmotic pressure, hemodynamic reactivity, and microvascular permeability during a protracted stress task in 26 healthy, young participants. Microvascular permeability was measured during rest using venous congestion plethysmography in a subsample of 13 participants. The task increased hematocrit, colloid osmotic pressure, blood pressure, and heart rate and decreased R-wave to pulse interval. Resting microvascular permeability was not correlated with hemoconcentration. Colloid osmotic pressure and diastolic blood pressure were associated with stress-induced hemoconcentration throughout the task. The association with systolic blood pressure as well as heart rate, however, was more evident during the initial 8 min of the task than throughout the total task duration. These findings suggest that factors associated with hemoconcentration vary with task duration.