Rate-dependent effects of d-amphetamine on locomotor activity in mice: Possible relationship to paradoxical amphetamine sedation in minimal brain dysfunction |
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| Authors: | Stanley D. Glick Svetlana Milloy |
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| Affiliation: | 1. Department of Pharmacology, Mount Sinai School of Medicine, Fifth Avenue and 100th Street, New York, New York 10029, USA;2. Herbert M. Singer Laboratory of neurosciences and Addictive Diseases, Beth Israel Medical Center, 307 Second Avenue, New York, New York 10003, U.S.A. |
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| Abstract: | Following a week of habituation to an activity cage, the locomotor activity of mice following a single dose (0, 1.0, 2.5, 5.0, 7.5 or 15.0 mg/kg) of d-amphetamine was measured. At all doses except 0 (saline), the effect of d-amphetamine on activity was inversely correlated with pre-drug baseline activity. These results demonstrate rate-dependent effects of d-amphetamine on locomotor activity and suggest that hyperkinesis per se would predispose to a sedative action of amphetamines in minimal brain dysfunction. |
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| Keywords: | Amphetamine Locomotor activity Minimal brain dysfunction |
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