Alterations in Cerebral Oxidative Metabolism following Traumatic Brain Injury |
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| Authors: | Michael De Fazio Richard Rammo Kristine O’Phelan M. Ross Bullock |
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| Affiliation: | (1) University of Miami, Miller School of Medicine, Miami, Florida, USA;(2) Department of Neurology and Jackson Memorial Hospital, University of Miami, Miller School of Medicine, Miami, Florida, USA;(3) Department of Neurological Surgery, Jackson Memorial Hospital and Lois Pope LIFE Center, University of Miami, Miller School of Medicine, Miami, Florida, USA; |
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| Abstract: | Background Traumatic brain injury (TBI) generates regional alterations in cerebral metabolism, leading to the potential evolution of persistent metabolic dysfunction. In the case of penetrating, firearm-related TBI, the pathophysiological mechanisms underlying these acute-phase metabolic derangements are not entirely understood—hindering the potential effectiveness of therapeutic intervention. The use of cerebral microdialysis to monitor biochemical alterations that occur, post-TBI, provides critical insight into the events that perpetuate neurological deterioration. |
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