糖化血红蛋白与糖尿病周围神经病变的相关性

目的探讨糖化血红蛋白与糖尿病周围神经病变程度的相关性。方法将100例糖尿病周围神经病变患者设为观察组，100名健康志愿者设为对照组，检测两组空腹血糖、餐后2h血糖、糖化血红蛋白，对检测结果进行对比分析。结果观察组糖化血红蛋白≥10．00％者占51．00％，显著高于对照组（Х^2=68．46，P〈0．01）；不同病变程度患者空腹血糖、餐后2h血糖、糖化血红蛋白水平均显著高于对照组（P〈0．05或0．01），患者随着病情的加重，空腹血糖、餐后2h血糖、糖化血红蛋白水平均逐渐升高（P〈0．01）。结论糖化血红蛋白水平与糖尿病周围神经病变程度具有一定的相关性，糖尿病周围神经病变程度越重，其糖化吼红蛋白水平越高。

Correlation between glycosylated hemoglobin and diabetic pe-ripheral neuropathy

Objective To explore the correlation between glycosylated hemoglobin and diabetic peripheral neuropathy （DPN）. Methods A total of 100 DPN patients were assigned to observation group and 100 healthy volunteers to control group. Fasting blood glucose （FBG）, 2-hour postprandial blood glucose （PBG） and glycosylated hemoglobin were detected and detection results analyzed. Results DPN patients with glycosylated hemoglobin ≥10.00% made up 51.00% in observation group, which was significantly higher compared with control group （Х^2 =68.46 ,P〈0.01） ; FBG, PBG and glycosylated hemoglobin levels in patients with different degrees of pathologic change were significantly higher in observation compared with control group （P〈0.05 or 0.01）, those generally increased along with exacerbation of patient＇s condition （P〈0.01）. Conclusion Glycosylated hemoglobin levels have a certain correlation with the degrees of diabetic perineuropathy, the severer the diabetic perineuropathy is, the higher glycosylated hemoglobin levels become.