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Diagnostic measures for sarcopenia and bone mineral density
Authors:A. Y. Bijlsma  M. C. G. Meskers  M. Molendijk  R. G. J. Westendorp  S. Sipilä  L. Stenroth  E. Sillanpää  J. S. McPhee  D. A. Jones  M. Narici  H. Gapeyeva  M. Pääsuke  E. Seppet  T. Voit  Y. Barnouin  J. Y. Hogrel  G. Butler-Browne  A. B. Maier
Affiliation:1. Department of Internal Medicine, Section of Gerontology and Geriatrics, VU University Medical Center, Postbus 7057, 1007, Amsterdam, The Netherlands
2. Department of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, The Netherlands
3. Department of Rehabilitation Medicine, Leiden University Medical Centre, Leiden, The Netherlands
4. Gerontology Research Center and Department of Health Sciences, University of Jyv?skyl?, Jyv?skyl?, Finland
5. Department of Biology of Physical Activity, University of Jyv?skyl?, Jyv?skyl?, Finland
6. School of Healthcare Science, Manchester Metropolitan University, Manchester, UK
7. School of Graduate Entry to Medicine and Health, Division of Clinical Physiology, University of Nottingham, Derby, UK
8. Institute of Exercise Biology and Physiotherapy, University of Tartu, Tartu, Estonia
9. Faculty of Medicine, Institute of Biomedicine, University of Tartu, Tartu, Estonia
10. Institute of Myology, GH Pitié-Salpêtrière, UPMC UM 76, INSERM U 974, CNRS UMR 7215, Paris, France
Abstract:

Summary

Currently used diagnostic measures for sarcopenia utilize different measures of muscle mass, muscle strength, and physical performance. These diagnostic measures associate differently to bone mineral density (BMD), as an example of muscle-related clinical outcome. These differences should be taken into account when studying sarcopenia.

Introduction

Diagnostic measures for sarcopenia utilize different measures of muscle mass, muscle strength, and physical performance. To understand differences between these measures, we determined the association with respect to whole body BMD, as an example of muscle-related clinical outcome.

Methods

In the European cross-sectional study MYOAGE, 178 young (18–30 years) and 274 healthy old participants (69–81 years) were recruited. Body composition and BMD were evaluated using dual-energy X-ray densitometry. Diagnostic measures for sarcopenia were composed of lean mass as percentage of body mass, appendicular lean mass (ALM) as percentage of body mass, ALM divided by height squared (ALM/height2), knee extension torque, grip strength, walking speed, and Timed Up and Go test (TUG). Linear regression models were stratified for sex and age and adjusted for age and country, and body composition in separate models.

Results

Lean mass and ALM/height2 were positively associated with BMD (P?P?P?Conclusions The associations between diagnostic measures of sarcopenia and BMD as an example of muscle-related outcome vary widely. Differences between diagnostic measures should be taken into account when studying sarcopenia.
Keywords:
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