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| 南瓜蛋白抗人慢性髓系白血病细胞系K562的作用研究 | |
| 引用本文： | 刘庭波,刘慧丽,谢捷明,胡建达.南瓜蛋白抗人慢性髓系白血病细胞系K562的作用研究[J].中国实验血液学杂志,2013,21(4):891-894. |
| 作者姓名： | 刘庭波 刘慧丽 谢捷明 胡建达 |
| 作者单位： | 1. 福建省血液病研究所,福建省血液病学重点实验室,福建医科大学附属协和医院,福建福州350001 2. 漳州卫生职业学院,福建漳州,363000 3. 福建医科大学药学院,福建福州,350004 |
| 基金项目： | 福建省血液病学重点实验室，福建省高校新世纪优秀人才计划 |
| 摘 要： | 本研究观察南瓜蛋白(Cucurmosin,CUS)在人慢性髓系白血病(CML)K562细胞-NOD/SCID小鼠的皮下移植瘤和白血病模型体内抗肿瘤活性。采用建立K562-NOD/SCID小鼠皮下移植瘤和白血病模型,分别使用二种模型评价CUS在小鼠体内的抗K562活性。结果表明,给药剂量为0.5 mg/kg和1 mg/kg的CUS对人CML皮下移植瘤的抑瘤率分别为53.45%和59.43%;而剂量为0.25 mg/kg和0.5 mg/kg的CUS给药组小鼠的生存时间分别为39.8±5.5 d和43.4±6.6 d,抑瘤率分别为24.9%和36%。结论:CUS对小鼠体内人CML细胞系K562具有显著的抑制作用。 |
| 关 键 词： | 南瓜蛋白 K562细胞 白血病模型 移植瘤模型 |
Effect of Cucurmosin on Chronic Myeloid Leukemia K562 Cell Line |
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| LIU Ting-Bo , LIU Hui-Li , XIE Jie-Ming , HU Jian-Da.Effect of Cucurmosin on Chronic Myeloid Leukemia K562 Cell Line[J].Journal of Experimental Hematology,2013,21(4):891-894. | |
| Authors: | LIU Ting-Bo LIU Hui-Li XIE Jie-Ming HU Jian-Da |
| Institution: | 1 Fujian Institute of Hematology,Fujian Provincial Key Laboratory of Hematology,Fujian Medical University Union Hospital,Fuzhou 350001,Fujian Province,China;1Zhangzhou School of Health Profession,Zhangzou 363000,Fujian Province,China;2College of Pharmacy,Fujian Medical University,Fuzhou 350004,Fujian Province,China ) |
| Abstract: | This study was aimed to investigate the antitumor effect of pumpkin protein（cucurmosin,CUS） on subcutaneous transplant tumor in chronic myeloid leukemia K562 cell-NOD/SCID mice and leukemia model.The subcutaneous transplant tumor in K562-NOD/SCID mice and leukemia model were established;using two models,the antitumor activity of CUS in mice was evaluated.The results indicated that the inhibitory rate of 0.5 mg/kg and 1 mg/kg CUS on subcutaneous transplant tumor were 53.45% and 59.43% respectively;survival time of mice received 0.25 mg/kg and 0.5 mg/kg CUS was 39.8±5.5 d and 43.4±6.6 d,antitumor rate was 24.9% and 36% respectively.It is concluded that CUS has significant inhibitory effect on mice with CML cell line K562. |
| Keywords: | cucurmosin K562 cell leukemia model transplant tumor model |
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