止痛巴布剂的体外透皮促进剂筛选

目的:优选止痛巴布剂的体外透皮促进剂.方法:采用Franz扩散池,以磷酸缓冲液pH 7.4为接收介质,经白兔腹部离体皮肤渗透,HPLC测定阿魏酸含量,计算药物累积透皮量和累积渗透率,考察透皮吸收促进剂氮酮、N-甲基-2-吡咯烷酮、丙二醇单独使用或混合使用对阿魏酸体外经皮渗透效果的影响.结果:最佳透皮促进剂为3％氮酮+3％丙二醇.N-甲基-2-吡咯烷酮几乎不能增加阿魏酸的透过量,单独加入2％氮酮使阿魏酸透过率增加1.7倍,单独加入3％丙二醇使阿魏酸得透过率增加1.4倍,3％氮酮与3％丙二醇联合使用使阿魏酸的透过率约增加2.2倍.结论:3％氮酮+3％丙二醇作为止痛巴布剂的透皮促进剂效果最好.

Screening of in vitro Transdermal Enhancer of Odynolysis Cataplasms

Objective: To optimize in vitro transdermal enhancer of odynolysis cataplasms. Method: Franz diffusion cell was adopted with pH 7.4 phosphate buffer as receiving medium,in vitro skin permeation studies of ferulic acid were conducted across excised rabbit abdominal skin.The content of ferulic acid was determined by HPLC to calculate cumulative doses of skin permeation and cumulative penetration rate.Effect of used alone or mixed use of azone,N-methyl-2-pyrrolidone and propylene glycol on in vitro transdermal of ferulic acid was investigated. Result: Optimum transdermal enhancer was 3% azone+3% propylene glycol,it could increase about 2.2 times of transdermal amount of ferulic acid.N-methyl-2-pyrrolidone could hardly increase transdrmal amount of ferulic acid,alone adding 2% azone could increase 1.7 times and 3% propylene glycol increased 1.4 times. Conclusion: 3% Azone+3% propylene glycol could be as transdermal enhancer for odynolysis cataplasms with optimum effect.