|
|||||
|
|
| 模拟失重大鼠血清及组织中内源性哇巴因的变化 | |
| 引用本文： | 刘朝霞,高广道,胡永杰,汪德生,吴大蔚,袁明,李志利.模拟失重大鼠血清及组织中内源性哇巴因的变化[J].航天医学与医学工程,2005,18(2):94-97. |
| 作者姓名： | 刘朝霞 高广道 胡永杰 汪德生 吴大蔚 袁明 李志利 |
| 作者单位： | 1. 西安交通大学医学院,陕西,西安,710061 2. 济南市历下区环保局,山东,济南,250014 3. 航天医学工程研究所,北京,100094 |
| 基金项目： | 国家自然科学资金资助(30400158) |
| 摘 要： | 目的检测模拟失重大鼠血清及组织中内源性哇巴因的含量,探讨其可能的病理生理学意义。方法20只雄性Wistar大鼠随机分为正常对照(Con)组及尾部悬吊30°模拟失重1周组(TS),酶联免疫吸附分析法检测血清及下丘脑、垂体、肾上腺、肾脏、心脏、肝脏中内源性哇巴因的含量。结果与对照组相比,模拟失重组血清、下丘脑、肾上腺及肾组织中内源性哇巴因的含量显著升高(P<0.05)。结论模拟失重引起大鼠血清及组织中内源性哇巴因含量改变,这可能对模拟失重状态下水电解质代谢及心血管功能新稳态的建立发挥一定的调节作用。 |
| 关 键 词： | 失重模拟 血清 组织 内源性哇巴因 电解质 |
| 文章编号： | 1002-0837(2005)02-0094-04 |
Changes of Endogenous Ouabain in Rat Serum and Certain Tissues after Exposure to Simulated Weightlessness |
|
| LIU Zhao-xia,GAO Guang-dao,HU Yong-jie,WANG De-sheng,WU Da-wei,YUAN Ming,LI Zhi-li.Changes of Endogenous Ouabain in Rat Serum and Certain Tissues after Exposure to Simulated Weightlessness[J].Space Medicine & Medical Engineering,2005,18(2):94-97. | |
| Authors: | LIU Zhao-xia GAO Guang-dao HU Yong-jie WANG De-sheng WU Da-wei YUAN Ming LI Zhi-li |
| Institution: | Department of Medicine, Xi'an Jiaotong University, Xi'an Shannxi, China. liuzx918@sohu.com |
| Abstract: | Objective To investigate the changes of endogenous ouabain (EO) in rat serum and some tissues after exposure to simulated weightlessness and to investigate its possible pathophysiology. Method Male Wistar rats were randomly divided into control group(Con) and 1 week tail-suspension group(TS). Enzyme-linked immunosorbent assay(ELISA) was used to detect the content of EO in serum, hypothalamus, pituitary, adrenal gland, kidney, heart and liver. Result Compared with Con, EO increased significantly in serum, hypothalamus, adrenal gland and kidney after tail suspension (P<0.05). Conclusion Simulated weightlessness induced changes of EO in serum and some tissues, which may have some effects on the regulation of hydro-electrolyte metabolism and cardiovascular functions. |
| Keywords: | weightlessness simulation serum tissues endogenous ouabain electrolytes |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |