| Abstract: | The effect of preliminary administration of sodium hydroxybutyrate (GHBA) on activation of the adrenergic and pituitary-adrenal systems during emotional-pain stress and on the severity of gastric ulcers after the end of such stress was studied in experiments on rats. Preliminary administration of GHBA was shown to restrict excitation of the systems responsible for stress and to prevent the development of ulceration of the gastric mucosa. It can be suggested that activation of the GABA-ergic inhibitory system arising during stress is the sole mechanism of limitation of the stress reaction and of prevention of stress-induced injuries.Laboratory of Pathophysiology of the Heart, Institute of General Pathology and Pathological Physiology, Academy of Medical Sciences of the USSR, Moscow. Central Research Laboratory, Irkutsk Medical Institute. (Presented by Academician of the Academy of Medical Sciences of the USSR A. M. Chernukh.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 88, No. 12, pp. 659–661, December, 1979. |
