Favorable histology, MYCN-amplified 4S neonatal neuroblastoma |
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| Authors: | Chan Edward L Harris Richard E Emery Kathleen H Gelfand Michael J Collins Margaret H Gruppo Ralph A |
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| Institution: | Division of Pediatric Hematology/Oncology, State University of New York at Stony Brook, Stony Brook, New York 11776, USA. elchan@notes.cc.sunysb.edu |
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| Abstract: | We report a neonate with 4S neuroblastoma and MYCN amplification, but favorable Shimada histology, successfully treated with chemotherapy and 13-cis-retinoic acid without stem cell transplantation. MYCN amplification in neuroblastoma is usually associated with unfavorable Shimada histology; the presence of these features in infants with 4S disease confers a poor prognosis. A small number of infants with 4S neuroblastoma and MYCN amplification have favorable Shimada histology. In this subgroup of infants, histopathology may be equally important in predicting outcome. |
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| Keywords: | bone marrow transplant MYCN amplification Shimada histology 4S neuroblastoma |
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