| 盐酸3—丙基氨甲基色满酮—4的降压作用 |
| |
| 引用本文： | 赵学慧,李柱天,朴在淳. 盐酸3—丙基氨甲基色满酮—4的降压作用[J]. 中国药理学通报, 1988, 0(1) |
| |
| 作者姓名： | 赵学慧 李柱天 朴在淳 |
| |
| 作者单位： | 延边医学院药理学教研室 吉林吉林省中医中药研究院药理室(赵学慧)，延边医学院药理学教研室 吉林(李柱天)，延边医学院药理学教研室 吉林(朴在淳) |
| |
| 摘 要： | 麻醉狗、大鼠iv盐酸3-丙基氯甲基色满酮-4(3-Propylami-nom ethy1-4 chromanone简称PAMC),麻醉家兔、大鼠十二指肠内注入PAMC,清醒肾型高血压大鼠ip或灌胃给药均有明显的降压作用。PAMC的降压作用主要与阻断α肾上腺素受体,兴奋血管的β_2受体和阻断神经节有关。
|
| 关 键 词： | 色满酮 降压作用 α肾上腺素受体 神经节阻断剂 |
RESEARCH ON THE HYPOTENSIVE EFFECT OF 3-PROPYLAMINOMETHYL-4-CHROMANONE HYDROCHLORIDE |
| |
| Zhao Xuehui,Li Zhutian and Piao Zaichun. RESEARCH ON THE HYPOTENSIVE EFFECT OF 3-PROPYLAMINOMETHYL-4-CHROMANONE HYDROCHLORIDE[J]. Chinese Pharmacological Bulletin, 1988, 0(1) |
| |
| Authors: | Zhao Xuehui Li Zhutian Piao Zaichun |
| |
| Abstract: | The hypotensive effect of PAMC and its mechanism were studied.In conscious renal hypertensive rats, intraperitonal injection of PAMC once a day for 7d at the dosage of 11 mg/kg ( 1 time/day ) and oral administration of the drug 3 times a day for 14 d at the dosage of 12 mg/kg/d, the arterial pressure decreased 29.0±2.8% and 20.3 ± 1.4%, respectively.In normal anesthetized dogs and rats, intravenous injection of PAMC at the dosage of 0.4 mg/kg, the mean arterial pressure deceased 43.7 ± 7.9 and 39.7 ± 2.3%. In anesthetized rabbits and rats, intraduodenal injection of PAMC at the dosage of 4 mg/kg, the mean arterial pressure decreased 24.5 ± 3.8% and 38.2 ± 11.4%, respectively.The experiments suggested that inhibition of the (?) -adrenal receptors may be the principal mechanism of the hypotensive action of PAMC. Ganglion blockade, vasodilation as Well as excitation of β2-adrenal receptors may also be involved.The acuts iv PAMC LD50 in mice were 25.5±5.0 mg/kg. |
| |
| Keywords: | Chromanone Hypotensive effect α-adrenal receptor Ganglion blockader |
| 本文献已被 CNKI 等数据库收录！ |
|
