盐酸3—丙基氨甲基色满酮—4的降压作用

麻醉狗、大鼠iv盐酸3-丙基氯甲基色满酮-4(3-Propylami-nom ethy1-4 chromanone简称PAMC),麻醉家兔、大鼠十二指肠内注入PAMC,清醒肾型高血压大鼠ip或灌胃给药均有明显的降压作用。PAMC的降压作用主要与阻断α肾上腺素受体,兴奋血管的β_2受体和阻断神经节有关。

RESEARCH ON THE HYPOTENSIVE EFFECT OF 3-PROPYLAMINOMETHYL-4-CHROMANONE HYDROCHLORIDE

The hypotensive effect of PAMC and its mechanism were studied. In conscious renal hypertensive rats, intraperitonal injection of PAMC once a day for 7d at the dosage of 11 mg/kg ( 1 time/day ) and oral administration of the drug 3 times a day for 14 d at the dosage of 12 mg/kg/d, the arterial pressure decreased 29.0±2.8% and 20.3 ± 1.4%, respectively. In normal anesthetized dogs and rats, intravenous injection of PAMC at the dosage of 0.4 mg/kg, the mean arterial pressure deceased 43.7 ± 7.9 and 39.7 ± 2.3%. In anesthetized rabbits and rats, intraduodenal injection of PAMC at the dosage of 4 mg/kg, the mean arterial pressure decreased 24.5 ± 3.8% and 38.2 ± 11.4%, respectively. The experiments suggested that inhibition of the (?) -adrenal receptors may be the principal mechanism of the hypotensive action of PAMC. Ganglion blockade, vasodilation as Well as excitation of β2-adrenal receptors may also be involved. The acuts iv PAMC LD50 in mice were 25.5±5.0 mg/kg.