延胡索对缺血再灌注损伤大鼠局灶性脑梗死的作用

目的：探讨延胡索对局灶性脑梗死的作用。方法：总共有30只Sprague-Dawley(SD)大鼠被用来研究。局灶性脑梗死动物模型的建立是将两侧的颈总动脉和右侧的中大脑动脉的血流阻断90min后，再经24h的灌注，然后评估它们的神经状态，大鼠被牺牲取脑，并作成切片用2，3，5-triphenyl-tetrazolium chloride染色。以神经的状态和脑梗死面积的变化作为指标来评估延胡索对脑梗死的作用。另外，24只SD大鼠腹腔注射延胡索，经24h后从心脏采血测量血液的变化。结果：延胡索100mg/kg腹腔注射能够改善大鼠神经缺损的症状和减少脑梗死的面积以及能增加全血中红血球的数目和提高血比容（hematocrit)。结论：延胡索在缺血再灌流损伤大鼠能改善神经状态和减少脑梗死面积。

Effect of Rhizoma Corydalis on focal cerebral infarct in ischemia-reperfusion injured rats

AIM: To investigate the effect of Rhizoma Corydalis (RC) on focal cerebral infarct. METHODS: A total of 30 Sprague-Dawley (SD) rats were studied. Focal cerebral infarct was established by occluding the bilateral common carotid arteries and the right middle cerebral artery for 90 min. After 24 h reperfusion, the neurological status was evaluated and then the rats were killed and the brain tissue was stained with 2,3, 5-triphenyl-tetrazolium chloride. The neurological status and the changes in the area of cerebral infarct were used as an index to evaluate the effect of RC on cerebral infarct. In addition, the whole blood was examined 24 h after RC treatment in the other 24 SD rats. RESULTS: Pretreatment with RC 100 mg/kg can improve neurological status and also can reduce the area of cerebral infarct in ischemia-reperfusion injured rats. The counts of erythrocyte and the amount of hematocrit increased in whole blood of RC-treated rats. CONCLUSION: RC can improve neurological status and reduce the area of cerebral infarct in ischemia-reperfusion injured rats.