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| 洛伐他丁缓释片的制备和体外释药的研究 | |
| 引用本文： | 邓蓉玲,何勤,张志荣,袁晓佳.洛伐他丁缓释片的制备和体外释药的研究[J].华西药学杂志,2001,16(4):265-266. |
| 作者姓名： | 邓蓉玲 何勤 张志荣 袁晓佳 |
| 作者单位： | 1. 四川省药品监督管理局, 2. 四川大学华西药学院, 3. 成都市第三人民医院, |
| 摘 要： | 目的：制备洛伐他丁缓释片，以降低其不良反应。方法：采用正交设计对片交设计对处方进行优化，并在人工胃液和人工肠液中考察了优化处方的溶出情况。结果：洛伐他丁缓释片在2、8、14h的累计百分释放度分别为11.97%、56.42%、82.15%。结论：洛伐他丁缓释片体外释药符合一级动力学方程。 |
| 关 键 词： | 洛伐他丁 缓释片 体外释药 制备 血药浓度 降血脂药 |
| 文章编号： | 1006-0103(2001)04-0265-02 |
| 修稿时间： | 2001年2月1日 |
PREPARATION OF SUSTAIND-RELEASE LOVASTATIN TABLET AND ITS RELEASE IN VITRO |
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| DENG Rong ling ,HE Qin ,ZHANG Zhi rong ,YUAN Xiao jia Sichuan Provincial Drug Administration,Chengdu ,China, West China School of Pharmacy,Sichuan University,Chengdu ,China, Chengdu Municipal rd Hospital,Chengdu.PREPARATION OF SUSTAIND-RELEASE LOVASTATIN TABLET AND ITS RELEASE IN VITRO[J].West China Journal of Pharmaceutical Sciences,2001,16(4):265-266. | |
| Authors: | DENG Rong ling HE Qin ZHANG Zhi rong YUAN Xiao jia Sichuan Provincial Drug Administration Chengdu China West China School of Pharmacy Sichuan University Chengdu China Chengdu Municipal rd Hospital Chengdu |
| Institution: | DENG Rong ling 1,HE Qin 2,ZHANG Zhi rong 2,YUAN Xiao jia 3 1 Sichuan Provincial Drug Administration,Chengdu 610041,China,2 West China School of Pharmacy,Sichuan University,Chengdu 610041,China, 3 Chengdu Municipal 3rd Hospital,Chengdu 6100 |
| Abstract: | OBJECTIVE:To prepare Sustained release lovastatin tablets METHODS:Orthogonol design was used to optimize the formulation and the release character was also studied in artificial gastric juice and intestinal juice.RESULTS:The cumulative release percentage of sustained release was 11.97%,56.42%,82.15% respectively at 2 hour,8 hour and 14 hour.CONCLUSION:The release of Lovastatin sustained release tablets in vitro accord with the first class equation |
| Keywords: | Lovastatin Sustained release tablet Formulation Release in vitro |
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