多烯磷脂酰胆碱对慢性乙型肝炎患者细胞因子及肝纤维化指标影响

目的研究多烯磷脂酰胆碱对慢性乙型肝炎(CHB)患者肝纤维化指标及细胞因子的影响。方法选择98例CHB患者随机分为治疗组(50例)和对照组(48例),治疗前后检测患者血清转化生长因子β1(TGF-β1)、肿瘤坏死因子α(TNF-α)、透明质酸(HA)、Ⅳ型胶原(C-Ⅳ)、层粘连蛋白(LN)以及丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)水平。结果治疗组患者血清ALT、AST、HA、C-Ⅳ、LN和TGF-β1、TNF-α水平较治疗前及对照组比较,均显著降低(P<0.01),差异均有统计学意义。结论多烯磷脂酰胆碱具有很强的抗氧化、保护肝细胞、抗感染及抗肝纤维化作用。

Effects of polyene phosphatidyl choline on cytokines and anti-fibrotic in patients with chronic hepatitis B

Objective To analyze the influence of polyene phosphatidyl choline（PPC） on liver fibrosis and cytokines in patients with chronic hepatitis B（CHB）.Methods Total of 98 cases with CHB were randomly divided into the treatment group（n = 50） and control group（n = 48）.The serum levels of transforming growth factor-β1（TGF-β1）,tumor necrosis factor-α（TNF-α）,hyaline acid（HA）,collagen type Ⅳ（C-Ⅳ）,laminin（LN）,alanine aminotransferase（ALT） and aspartate aminotransferase（AST） in those patients were detected before and after treatment.Results After treatment,the serum levels of TGF-β1,TNF-α,ALT,AST,HA,C-Ⅳ and LN in treatment group were significantly reduced,and lower than those in control group（P 〈0.01）.Conclusions PPC has strong antioxidant,cytoprotective,anti-inflammatory and anti-fibrotic effects.