| VEGF165cDNA治疗缺血心肌的实验研究 |
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| 引用本文： | 蒋国顺,朱朗标,高长青,李功松,张向华. VEGF165cDNA治疗缺血心肌的实验研究[J]. 中国现代医学杂志, 2003, 13(4): 7-9 |
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| 作者姓名： | 蒋国顺 朱朗标 高长青 李功松 张向华 |
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| 作者单位： | 1. 解放军第309医院胸心外科,100091
2. 解放军总医院心外科 |
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| 摘 要： | 目的：观察VEGFl65cDNA治疗缺血心肌后心功能、血流动力学、心肌灌注和代谢的变化。方法：健康杂种犬36只，随机分为VEGFl65cDNA和空质粒(pcDNA3：1)组(n＝12)，心肌梗塞组为对照组。Amroid环致慢性心肌缺血模型。VEGFl65基因转染采用直接心肌注射法。结果：基因转染后4周、8周时VEGF165基因组LVEF和CO及前壁、前侧壁、前间壁心肌灌注量、代谢和FDG摄入量明显高于同期心肌梗塞组。结论：VEGFl65基因治疗后4周和8周时心功能显著改善；成活心肌的数量显著增加和/或称成活心肌功能显著恢复。
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| 关 键 词： | 基因 心肌梗塞 灌注 代谢 内皮细胞生长因子 实验 慢性心肌缺血模型 |
| 修稿时间： | 2002-05-19 |
EXPERIMENTAL STUDY OF VEGF165cDNA IN TREATMENT FOR MYOCARDIAL ISCHEMIA |
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| Jiang Guoshun,Zhu Langbiao,Gao Changqing,et al.. EXPERIMENTAL STUDY OF VEGF165cDNA IN TREATMENT FOR MYOCARDIAL ISCHEMIA[J]. China Journal of Modern Medicine, 2003, 13(4): 7-9 |
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| Authors: | Jiang Guoshun Zhu Langbiao Gao Changqing et al. |
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| Affiliation: | Jiang Guoshun,Zhu Langbiao,Gao Changqing,et al. Department of Cardio-thorac,309th Hospital of PLA,Beijing 100091$$$$ |
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| Abstract: | Objective:To determine the changes of cardiac function, metabolism and myocardial perfusion of ischemia myocardium after administrating VEGF165cDNA.Methods:Thirty-six dogs were randomly divided into (n=12) plasmid VEGF165cDNA and pcDNA3. 1(+/-5.1),and myocardial infarction served as control group. Left anterial decending artery were ligated with ameroid constrictor.Result:The amount of perfusion and intake of FDG of anterial ,anterial lateral and anterial septum wall of left vetricle in VEGF165 gene plasmid group were larger than that of control group after four weeks and eight weeks, respectively.Conclusion:The quantity of viable myocardium are strikingly increased and/or the function of viable myocardium are strikingly recovered after intramyocardial administration of VEGF 165 gene. |
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| Keywords: | Gene Myocardial Ischemia Perfusion Metabolism |
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