| 盐酸他可林在大鼠体内的分布和排泄 |
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| 引用本文： | 印晓星,唐性春.盐酸他可林在大鼠体内的分布和排泄[J].徐州医学院学报,1997,17(4):343-346. |
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| 作者姓名： | 印晓星 唐性春 |
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| 作者单位： | Department of Pharmacology，Xuzhou Medical College，Xuzhou，Jiangsu 221002，China |
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| 基金项目： | 江苏省教委自然科学基金 |
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| 摘 要： | 目的 研究盐酸他可林（ＴＨＡ）在大鼠体内的分布和排泄。方法 大鼠以剂量８ｍｇ／ｋｇ灌胃给予盐酸他可林后，在规定时间摘取各脏器，收集尿粪，提取后用高效液相法测定浓度，分别计算药物在各组织的分布和排泄。结果 ６９％的药物由尿排泄，２４％的药物由粪排泄。在尿粪中原形药ＴＨＡ仅占３．１％。而１－ＯＨ－ＴＨＡ和２－ＯＨ－ＴＨＡ分别为４２．０％放３５．５％，结论 盐酸他可林在大鼠体内的清除途径以羟代谢为主，药
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| 关 键 词： | 盐酸他可林 分布 血药浓度 高压液相色谱法 |
THE DISTRIBUTION AND EXCRETION OF TACRINE IN RATS |
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| Yin Xiaoxing,Tang Xingchun,Yan Mei,et al.THE DISTRIBUTION AND EXCRETION OF TACRINE IN RATS[J].Acta Academiae Medicinae Xuzhou,1997,17(4):343-346. |
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| Authors: | Yin Xiaoxing Tang Xingchun Yan Mei |
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| Abstract: | Objective To study the distribution and excretion of tacrine (THA)in rats.Methods After ig THA 8 mg/kg,the samples of blood,urine,feces and organ tissues were collected and the drug concentrations in plasma,urine,feces and various tissues were determined by HPLC.Results About 69% of the oral dose was eliminated in urine,while 24% of the oral dose was eliminated in feces.THA,1-OH-THA,and 2-OH-THA in urine and feces accounted for 3.1%,42.0%,and 35.5% of the oral dose respectively.Conclusion The major metabolism route for THA is hydroxylation,and the concentration of THA in tissues decreases as follows,brain,liver,blood,kidney,fat,lung,spleen,testis,stomach,heart,duodenum and muscle. |
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| Keywords: | Tacrine Distribution Metabolism Excretion Chromatography high pressure liquid Rat |
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