奥扎格雷钠对急性脑梗死患者神经功能状态及脑血流的影响

目的：观察奥扎格雷钠对急性脑梗死患者神经功能状态及脑血流的影响。方法：将本院收诊的急性脑梗死患者随机分成两组，对照组和观察组各102例，对照组采用基础治疗，观察组在此基础上加用奥扎格雷钠注射液。治疗前及治疗后采用欧洲卒中量表（ESS）及肢体运动功能评分量表（Fugl—mey—er）对两组神经功能状态进行评价，同时检测血清中去甲肾上腺素、尿儿茶酚胺、磷酸酯、超敏C-反应蛋白（hs-CRP）含量。治疗前及治疗后对两组大脑中动脉血流状态和血液流变学进行比较。结果：治疗7、14d后，观察组ESS和Fugl—meyer量表得分明显高于对照组，血清中去甲肾上腺素（NA）、尿儿茶酚胺（CA）、磷酸酯（PA）、hs—CRP水平明显低于对照组，差异具有统计学意义（P〈0．05）；另外观察组全血高切黏度、全血低切黏度和血清纤维蛋白原水平明显低于对照组，凝血时间明显长于对照组，差异具有统计学意义（P〈0．05）；观察组大脑中动脉血平均收缩期峰值流速（PSV）、舒张末期血流速度（EDV）、血流速度（Vm）明显快于对照组，血管搏动指数（PI）明显高于对照组，阻力指数（RI）则明显低于对照组，差异均具有统计学意义（P〈0．05）。结论：奥扎格雷钠能有效改善急性脑梗死患者大脑血流供应，促进患者神经功能的恢复。

Influence of Sodium Ozagrel on neurological state and cerebral blood flow of patients with a- cute cerebral infarction

Objective： To observe the influence of Sodium Ozagrel on the neurological state and cerebral blood flow of patients with acute cerebral infarction. Methods：Patients with acute cerebral infarc- tion admitted to our hospital from April 2010 to April 2013 were randomly divided into control group and observation group, with 102 cases in each group,patients in control group were given conventional treat- ment, while those in observation group were treated by conventional treatment combined with Sodium Ozagrel. Then the ESS and Fugl-meyer scale were used to evaluate the neurological state, the serum levelsof norepinephrine, urinary catecholamines, phosphate, hs-CRP of two groups were also detected and com- pared. And blood flow of arterial in the brain and the hemodynamic of two groups were also compared. Results. After 7, 14 days of treatment, the scores of the ESS and Fugl-meyer scale of observation group were significant higher than that of control group, the serum levels of norepinephrine, urinary cate- cholamines, phosphate, hs-CRP were lower than control group （P〈0.05） ; the high shear whole blood viscosity and low shear whole viscosity blood of the observation group were lower and indexes of PSV , EDV and Vm were faster than control group; the indexes of PI were higher, the indexes of RI were lower than control group （all P〈0.05）. Oonclusion： Sodium Ozagrel can effectively improve the supply of cere- bral blood, promote the recovery of neurological function in patients with acute cerebral infarction .