hs-CRP、CK-MBmass和cTnI联合检测在小儿病毒性心肌炎诊断中的价值

目的：探讨联合检测心肌肌钙蛋白I（cTnI）、肌酸激酶同工酶质量（CK-MBmass）和高敏c反应蛋白ths-CRP）在小儿病毒性心肌炎诊断中的价值。方法：本研究分为3组，病毒性心肌炎组（VMC）60例，疑似病毒性心肌炎组（NVMC）57例，健康对照组62例。抽取3组儿童静脉血5mL，分别测定各组血清cTnI、CK-MBmass和hs-CRP水平，并进行比较。结果：VMC组hs-CRP、CK-MBmass和cTnI的水平均升高，明显高于NVMC组和对照组（P〈0．05）；hs-CRP在血清中消失较快，cTnI在血液中存在时间最长；hs-CRP的灵敏度最高（75．0%），cTnI的特异性最好（89．4％），3个指标联合检测的灵敏度为93．3％，特异度为96．5％，准确率为94．9％。结论：联合检测cTnI、CK-MBmass和hs-CRP的血清水平更能准确诊断小儿病毒性心肌炎，对建立更准确的病毒性心肌炎的诊断标准有重要意义。

Value of joint detection of cTnl,OK - MB mass and hs - CRP in pediatric VMC

Objective： To investigate the joint detection of cTnI, CK -MB mass and hs -CRP in pe- diatric viral myocarditis（VMC）. Methods： All patients were divided into three groups： Viral myocarditis group （VMC, n=60）, suspected viral myocarditis group （NVMC, n=57） and healthy control group （n= 62）. Five mL of venous blood was extracted, the serum levels of cTnI, CK-MB mass and hs-CRP were de- termined. Results： In VMC group hs CRP, CK -MB mass and cTnI levels were significantly higher than those of NVMC group and control group （P〈0.05）. hs-CRP in serum disappeared quickly, and existence time of cTnI was the longest, hs-CRP showed the highest sensitivity（75.0%）and cTnI showed best speci- ficity（89.4%）. The sensitivity of combination detection was 93.3%, specificity was 96.5% and the accu- racy was 94.9%. Conclusion： Joint detection of cTnI, CK-MB mass and hs-CRP is accurate in diagnosis the pediatric viral myocarditis.