| 鱿鱼皮胶原蛋白多肽对B16黑素瘤细胞黑素合成的影响 |
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| 引用本文： | 王静凤,王奕,崔凤霞,李八方,薛长湖. 鱿鱼皮胶原蛋白多肽对B16黑素瘤细胞黑素合成的影响[J]. 中国药理学通报, 2007, 23(9): 1181-1184 |
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| 作者姓名： | 王静凤 王奕 崔凤霞 李八方 薛长湖 |
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| 作者单位： | 中国海洋大学食品科学与工程学院,山东,青岛,266003 |
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| 基金项目： | 国家高技术研究发展计划(863计划)目标导向资助项目 |
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| 摘 要： | 目的研究不同分子量鱿鱼皮胶原蛋白多肽SP1(Mr>10000u)、SP2(6000u
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| 关 键 词： | 鱿鱼皮胶原肽 B16黑素瘤细胞 黑素合成 酪氨酸酶 mRNA表达 |
| 文章编号： | 1001-1978（2007）09-1181-04 |
| 修稿时间： | 2007-03-272007-05-23 |
Effects of collagen polypeptides from squid (Dosidicus gigas)skin on melanogenesis in B16 melanoma cells |
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| WANG Jing-feng,WANG Yi,CUI Feng-xia,LI Ba-fang,XUE Chang-hu. Effects of collagen polypeptides from squid (Dosidicus gigas)skin on melanogenesis in B16 melanoma cells[J]. Chinese Pharmacological Bulletin, 2007, 23(9): 1181-1184 |
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| Authors: | WANG Jing-feng WANG Yi CUI Feng-xia LI Ba-fang XUE Chang-hu |
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| Affiliation: | College of Food Science and Engineering, Ocean University of China, Qingdao Shandong 266003, China |
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| Abstract: | Aim To study the effects of different molecular weight of collagen polypeptides from squid(Dosidicus gigas)skin(SP1:Mr>10000 u,SP2:6 000 u0.05),the melanogenesis and tyrosinase activity were inhibited remarkably(P<0.05,P<0.01).The TYR mRNA level was decreased evidently(P<0.05,P<0.01) in a dose dependent manner by SP1,SP2 and SP3,respectively.Conclusion Different molecular weight of collagen polypeptides from squid(Dosidicus gigas)skin can inhibit melanogenesis in B16 melanocytes observably.The inhibition effect of SP2 is better than that of SP1 and SP3(P<0.05). |
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| Keywords: | squid(Dosidicus gigas)skin collagen polypeptide B16 melanoma cells melanogenesis tyrosinase mRNA expression |
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