| EFFECT OF ELECTROACUPUNCTURE ON SERUM IL-1β AND TNF-α CONTENTS IN CEREBRAL ISCHEMIA-REPERFUSION RATS |
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| 引用本文： | 陈玲,骆明军,明建扩,陈邦国. EFFECT OF ELECTROACUPUNCTURE ON SERUM IL-1β AND TNF-α CONTENTS IN CEREBRAL ISCHEMIA-REPERFUSION RATS[J]. 世界针灸杂志, 2003, 13(4) |
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| 作者姓名： | 陈玲 骆明军 明建扩 陈邦国 |
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| 作者单位： | Dept. of Acu moxibustion of Shanghai East Hospital，Hubei College of TCM，Tongji Medical College of Central China University of Science and Technology，Hubei College of TCM Shanghai 200120，Wuhan 430061，Wuhan 430061，Wuhan 430061 |
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| 摘 要： | Purpose: To study the mechanism of early acupuncture treatment in resisting inflammatory injury in cerebral ischemia-reperfusion (IR) rats. Methods: A total of 120 Wistar rats were randomly divided into normal control, sham-operation, model and EA groups, and each of them were further divided into IR-12 hr, IR-24 hr and IR-48 hr subgroups, with 10 cases being in each subgroup. Cerebral ischemia was produced by occlusion of the middle cerebral artery for 0.5 hr. Shuigou (GV 26) and Baihui (GV 20) were punctured and stimulated electrically with an EA therapeutic apparatus. Serum IL-1β and tumor necrosis factor (TNF)-α contents were assayed by using radioimmunoassay.Results: Results showed that serum IL-1β and TNF-c contents of model group were significantly higher than those of normal control and sham-operation groups at IR 12 hr, 24 hr and 48 hr ( P ＜ 0.05), meaning that following IR, the production and release of these two cytokines in the blood increased obviously; comparison between EA and model groups displayed that serum IL-1β and TNF-α levels of EA group were strikingly lower than those of model group (P＜0.01),suggesting that EA stimulation can suppress IR induced increase of production and release of these two cytokines. Conclusion: EA can suppress cerebral IR induced increase of serum IL-1β and TNF-α, which may contribute to the effect of acupuncture in resisting cerebral IR injury in the treatment of stroke.
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| 关 键 词： | Cerebral ischemia,Electroacupuncture,Serum IL-1β and TNF-α |
EFFECT OF ELECTROACUPUNCTURE ON SERUM IL-1β AND TNF-α CONTENTS IN CEREBRAL ISCHEMIA-REPERFUSION RATS |
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| CHEN Ling LUO Ming jun MING Jian kuo CHEN Bang guo Dept. of Acu moxibustion of Shanghai East Hospital,Shanghai , Hubei College of TCM,Wuhan , Tongji Medical College of Central China University of Science and Technology,Wuhan. EFFECT OF ELECTROACUPUNCTURE ON SERUM IL-1β AND TNF-α CONTENTS IN CEREBRAL ISCHEMIA-REPERFUSION RATS[J]. World Journal of Acupuncture-Moxibustion, 2003, 13(4) |
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| Authors: | CHEN Ling LUO Ming jun MING Jian kuo CHEN Bang guo Dept. of Acu moxibustion of Shanghai East Hospital Shanghai Hubei College of TCM Wuhan Tongji Medical College of Central China University of Science Technology Wuhan |
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| Affiliation: | Dept, of Acu-moxibustion of Shanghai East Hospital, Shanghai 200120 Hubei College of TCM, Wuhan 430061 Tongji Medical College of Central-China University of Science and Technology,Wuhan 430061 Hubei College of TCM, Wuhan 430061 |
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| Abstract: | |
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| Keywords: | Cerebral ischemia Electroacupuncture |
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