| 顶空气相色谱法测定夫西地酸中有机溶剂残留量 |
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| 引用本文： | 栾成章,祝波,王尊文,王亮.顶空气相色谱法测定夫西地酸中有机溶剂残留量[J].中国药房,2006,17(7):535-536. |
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| 作者姓名： | 栾成章 祝波 王尊文 王亮 |
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| 作者单位： | 青岛市药品检验所,青岛市,266071 |
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| 摘 要： | 目的:建立以顶空气相色谱法测定夫西地酸中有机溶剂残留量的方法。方法:色谱柱为聚乙二醇20000DM-WAX毛细管柱,柱温采取程序升温,检测器温度为250℃,载气为氦气,流速为7ml/min,分流比为1∶1。结果:有机溶剂丙酮、甲醇、乙醇检测浓度线性范围分别为2.04~102.50μg/ml(r=0.9992)、2.00~99.98μg/ml(r=0.9995)、2.04~102.34μg/ml(r=0.9995),平均回收率分别为98.7%、99.2%、101.7%,RSD分别为2.11%、1.98%、2.01%。结论:本方法简便、结果准确,适用于夫西地酸中有机溶剂残留量的测定。
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| 关 键 词： | 夫西地酸 顶空气相色谱法 有机溶剂 残留量 |
| 文章编号： | 1001-0408(2006)07-0535-02 |
| 收稿时间： | 02 13 2006 12:00AM |
| 修稿时间： | 03 1 2006 12:00AM |
Determination of Organic Solvent Residual Volume in Fusidic Acid by Headspace Gas Chromatography |
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| LUAN Chengzhang,ZHU Bo,WANG Zunwen,WANG Liang.Determination of Organic Solvent Residual Volume in Fusidic Acid by Headspace Gas Chromatography[J].China Pharmacy,2006,17(7):535-536. |
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| Authors: | LUAN Chengzhang ZHU Bo WANG Zunwen WANG Liang |
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| Institution: | Qingdao Institute for Drug Control, Qingdao 266071, China |
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| Abstract: | OBJECTIVE:To determine organic solvent residual volume in fusidic acid by headspace gas chromatography.METHODS:The determination was performed on polyoxyl20000DM-WAX capillary,the column was subjected to tempera-ture programming,the detector temperature was250℃,the carrier gas was helium,the flow rate was7ml/min and the split ratio was1∶1.RESULTS:The linear detective concentration ranges of acetone,methanol and ethanol were2.04～102.50μg/ml(r=0.9992),2.00～99.98μg/ml(r=0.9995)and2.04～102.34μg/ml(r=0.9995),respectively,their average recovery rates were98.7%,99.2%and101.7%,respectively with RSD at2.11%,1.98%and2.01%,respectively.CONCLUSIONS:The method is simple,accurate,and suitable for the determination of organic solvent residual volume in fusidic acid. |
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| Keywords: | Fusidic acid Headspace gas chromatography Organic solvent Residual volume |
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