糖皮质激素对鼻息肉组织中eotaxin蛋白的影响

目的：探讨糖皮质激素治疗鼻息肉的可能机制。方法：随机将15例鼻息肉患者均分为强的松治疗组、地塞米松治疗组和未治疗组，以同期手术的5例鼻中隔偏曲者的下鼻甲黏膜组织作对照，用免疫组化法测定鼻息肉组织中嗜酸细胞趋化因子（eotaxin）蛋白的表达。结果：激素未治疗组eotaxin蛋白的表达比对照组显著增高（P＜0.01）；激素治疗组eotaxin蛋白表达下降，与未治疗组比较差异有统计学意义（P＜0.01）,与对照组比较差异无统计学意义（P＞0.05）。结论： eotaxin蛋白是诱导嗜酸细胞在鼻息肉组织中浸润的重要趋化因子,糖皮质激素可下调eotaxin蛋白的表达,发挥抗嗜酸细胞炎症的作用。

Effect of glucocorticoids on eotaxin expression in nasal polyps

Objective： To explore the possible mechanism of glucocorticoids on nasal polyps. Methods： Eotaxin protein expression was measured by immunohistochemical techniques in 5 nasal polypous tissue specimens following 30 mg predisone oral doses per day for 7 days, 5 nasal polypous tissue specimens following 10 mg dexamethasone intravenous drops, 5 without any treatment and compared with the results from the inferior turbinate tissue specimens. Results： The protein level of eotaxin significantly elevated in the nasal polyps compared to the controls (P＜0.01), whereas it significantly decreased in the treatment group compared with the untreatment group(P＜0.01), and similar to the controls（P＞0.05）. Conclusion： Because eotaxin actively participates in the process of eosinophilic inflammation, glucocorticoids play an important role in anti inflammation by down regulation of eotaxin.