TH1 and TH2 T-cell subsets are differentially activated by macrophages and B cells in murine leishmaniasis. |
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Authors: | B Rossi-Bergmann I Müller and E B Godinho |
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Institution: | B Rossi-Bergmann, I Müller, and E B Godinho |
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Abstract: | The role of antigen-presenting cells in the differential expansion of TH1 and TH2 T cells in murine leishmaniasis was investigated. In general, macrophages preferentially induced gamma interferon and interleukin-2 secretion by syngeneic Leishmania-specific T cells, whereas B cells were more efficient in activating interleukin 4 production. B cells from susceptible BALB/c mice were better in inducing TH2 responses than B cells from resistant C57BL/6 mice, whereas macrophages from C57BL/6 mice were superior to BALB/c macrophages in inducing TH1 responses. |
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