Modeling complex genetic and environmental influences on comorbid bipolar disorder with tobacco use disorder |
| |
| Authors: | Richard C McEachin Nancy L Saccone Scott F Saccone Yelena D Kleyman-Smith Tiara Kar Rajesh K Kare Alex S Ade Maureen A Sartor James D Cavalcoli Melvin G McInnis |
| |
| Affiliation: | (1) Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA;(2) National Center for Integrative Biomedical Informatics, University of Michigan, Ann Arbor, MI, USA;(3) Department of Genetics, Washington University, Saint Louis, MO, USA;(4) Department of Psychiatry, Washington University, Saint Louis, MO, USA;(5) Department of Biology, Eastern Michigan University, Ypsilanti, MI, USA |
| |
| Abstract: | Background Comorbidity of psychiatric and substance use disorders represents a significant complication in the clinical course of both disorders. Bipolar Disorder (BD) is a psychiatric disorder characterized by severe mood swings, ranging from mania to depression, and up to a 70% rate of comorbid Tobacco Use Disorder (TUD). We found epidemiological evidence consistent with a common underlying etiology for BD and TUD, as well as evidence of both genetic and environmental influences on BD and TUD. Therefore, we hypothesized a common underlying genetic etiology, interacting with nicotine exposure, influencing susceptibility to both BD and TUD. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
