不同言语加工水平受损的汉语失语症患者的事件相关电位

目的:本研究采用事件相关电位(ERPs)技术考察了汉语失语症患者言语产生过程中语义和语音的编码情况.方法:根据“汉语失语症心理语言评价(PACA)”得分结果将14例失语症患者分为词汇语义损伤、词汇通达障碍、词汇语音损伤3组不同言语加工水平损伤组,采用ERPs作为技术手段,实验任务为延迟命名,观察患者的脑电情况,记录15名健康人的脑电图作为对照.结果:词汇语义损伤为主的患者异常波幅出现在400ms以前,词汇通达障碍为主的患者异常波幅出现在介于400ms前后的时间窗,而词汇语音损伤为主的患者异常波幅出现在400ms以后的时间窗,每种类型其异常波幅出现的时间窗有较大的重叠.结论:ERPs可作为探讨汉语失语症病态内部语言的过程,以及辅助失语症评价的重要工具.

The event-related-potentials study of Chinese aphasia patients with different impaired encoding process during word production

AbstractObjective: To investigate the time course of semantic and phonological encoding during word production in Chinese aphasia patients by event-related-potentials (ERPs) technology. Method: Delaying picture naming task was used during ERPs study to analyze electrophysiological correlation of different patterns of aphasia. Fourteen aphasic patients were divided into three subgroups according to psycholinguistic assessment in Chinese aphasia (PACA): lexical-semantic impairment, lexical-access impairment and lexical-phonological impairment, compared to 15 healthy control subjects performing the same picture naming task. Result: The subgroup with lexical-semantic impairment had abnormal ERPs patterns before 400ms, the subgroup with lexical-access impairment had abnormal ERPs patterns between before and after 400ms, the subgroup with lexical-phonological impairment had abnormal patterns after 400ms. The time course of abnormal ERPs patterns in different group had much overlap. Conclusion: ERPs can be used as a tool to explore the internal language process in a morbid state and to assist evaluating the aphasia.