| 糖尿病大鼠肾脏抗氧化防御系统机能的改变 |
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| 引用本文： | 王柏欣,张福,路雅真,张建华,李凯霞. 糖尿病大鼠肾脏抗氧化防御系统机能的改变[J]. 黑龙江医药科学, 2004, 27(3): 4-5 |
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| 作者姓名： | 王柏欣 张福 路雅真 张建华 李凯霞 |
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| 作者单位： | 佳木斯大学基础医学院,黑龙江,佳木斯,154002;双鸭山矿业集团第二医院,黑龙江,双鸭山,155100 |
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| 摘 要： | 目的：探讨糖尿病对肾脏抗氧化防御机能的影响。方法：观察12周糖尿病大鼠肾皮质丙二醛(MDA)及谷胱甘肽(GSH)水平，以及超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)、谷胱甘肽S转移酶(GSH-ST)和过氧化氢酶(CAT)活性的变化。结果：糖尿病大鼠肾组织中SOD、CAT活性下降；GSH含量显著降低；MDA没有变化；GSH-PX活性却明显增强。结论：糖尿病大鼠肾组织抗氧化防御机能明显下降。
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| 关 键 词： | 糖尿病肾病 氧化还原 应激 自由基 |
| 文章编号： | 1008-0104(2004)03-0004-02 |
| 修稿时间： | 2004-03-01 |
Antioxidant defense system in the kidney of diabetic rats |
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| WANG Bai-xin,ZHANG Fu,LU Ya-zhen,ZHANG Jian-hua,LI Kai-xia. Antioxidant defense system in the kidney of diabetic rats[J]. Heilongjiang Medicine and Pharmacy, 2004, 27(3): 4-5 |
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| Authors: | WANG Bai-xin ZHANG Fu LU Ya-zhen ZHANG Jian-hua LI Kai-xia |
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| Affiliation: | WANG Bai-xin1,ZHANG Fu2,LU Ya-zhen1,ZHANG Jian-hua1,LI Kai-xia1 |
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| Abstract: | Objective:To determine whether diabetes had an effect on renal antioxidant defense function. Methods: The levels of malondialdehyde(MDA), glutathione(GSH), and the activities of antioxidant enzymes superoxide dismutase(SOD), glutathione peroxidase(GSH-PX), and catalase(CAT) were investigated in the renal cortex of diabetic rats at week12. Results:The activities of SOD and CAT were significantly lower in the diabetic group than normal one. The level of GSH was decreased too, MDA showed no change, whereas GSH-PX activity of the diabetic group was increased. Conclusion:The antioxidant defense function in the kidney of diabetic rats decreased significantly suggesting an obvious effect of diabetes on the defense function. |
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| Keywords: | diabetic nephropathy oxidative reduction stress free radicals |
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