Comparison of lipid peroxidation parameters in the heart,liver, and brain of rats with different degrees of resistance to hypoxia |
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| Authors: | M L Khachatur'yan V M Gukasov P G Komarov L B Pirogova M V Bilenko |
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| Institution: | (1) Department of Experimental Biological Models, Russian State Medical University, Moscow, USSR;(2) Department of Biological Methods, Russian State Medical University, Moscow, USSR;(3) Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, USSR |
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| Abstract: | The relationship between the intensity of lipid peroxidation and the activity of the antioxidant system in the heart, liver,
and brain is studied in male Wistar rats with low and high resistance to hypoxia tested by being “raised” to an altitude of
11.5 km and in intact outbred rats. It is found that in all groups of rats the content of lipid peroxidation products is highest
in the liver, lower in the heart, and lowest in the brain. In all groups, the rate of the ascorbate-induced lipid peroxidation
is highest in the brain, lower in the liver, and lowest in the heart. The activity of the antioxidant system is highest in
the brain, lower in the liver, and lowest in the heart of low-resistance and outbred rats, while in high-resistance rats it
is the same in all the organs. Thus, the difference in the parameters of lipid peroxidation and, particularly, of the antioxidant
system in the studied organs is most pronounced in rats with a low resistance to hypoxia.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
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2, pp. 138–143, February, 1996
Presented by A. I. Archakov, Member of the Russian Academy of Medical Sciences |
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| Keywords: | lipid peroxidation antioxidant system hypoxia low resistance high resistance |
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