胸腔内注入顺铂联合长春地辛治疗恶性胸腔积液疗效对比

目的 探讨胸腔内注入顺铂（DDP）联合长春地辛（VDS）治疗恶性胸腔积液的疗效。方法 病理确诊的恶性胸腔积液60例，经胸腔插管引流术排尽胸液后，按随机化原则分为2组，治疗组（32例）在胸腔内注入DDP40mg/m∧2，VDS4mg，对照组（28例）在胸腔内注入DDP40mg/m∧2，1周后重复1次，观察疗效、生活质量、生存率以及毒副反应。结果 治疗组总有效率81％，病变进展率3％，较对照组50％，25％差异有显著性（P＜0．05）。Kamofsky评分大于70分治疗组较对照组有显著提高（P＜0．05）。治疗组0．5年、1年、1．5年、2年的生存率为97％、59％、44％、6％，分别高于对照组的71％、50％、14％、4％，其中0．5，1．5年的生存率差异有显著性（P＜0．05）。治疗组I度白细胞下降较对照组明显。 结论 胸腔内联合注入DDP和VDS治疗恶性胸腔积液是一种有效的、副反应小、可耐受的方法。

Treatment of malignant pleural effusion using vindesine and cisplatine intrapleurally injection(observation of 60 cases)

Objective To evaluate the efficacy of treating malignant pleural effusion with cisplatine and vindesine by injection through thoracic tube intubation. Methods 60 cases with malignant pleural effusion,after drainage,vindesine 4 mg,cisplatine 40 mg/m 2 were injectred into pleural cavity in therapy group(T),and only cisplatine 40 mg/m 2 in control group (C) the tretment was repeated after a week,then evaluate the efficacy,survival rate,toxicities and quality of life. Results The response rate was 81% in T group and 50% in C group There was statistical difference in two groups ( P <0 05) The Karnofsky score is higher in T group than in C group The half year,one year,one and half year,two year survival rates were 97%,59%,44%,6% in T group and 71%,50%,14%,4% in C group Grade I leukopenia is higher in T group than in C group. Conclusion The treatment to use Vindesine and cisplatine through thoracic tube is regarded as effective,slight side effect and welltolerated method for malignant pleural effusion