Langerhans cells in vulvar lichen sclerosus and vulvar squamous cell carcinoma |
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Authors: | Helena Rotsztejn Ewa Trznadel-Budźko Dorota Jesionek-Kupnicka |
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Institution: | (1) Section of Dermatology, Research Institute of the Polish Mother’s Memorial Hospital, Rzgowska 281/284, 93-338 Łódź, Poland;(2) Department of Dermatology and Pediatric Dermatology, Military-Medical Faculty, Medical University of Łódź, Łódź, Poland;(3) Department of Tumor Pathology, Chair of Oncology, Medical University of Łódź, Łódź, Poland |
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Abstract: | Introduction: Langerhans cells (LCs), specializing in antigen presentation, are a very important part of the skin immune system (SIS).
Materials and Methods: Skin biopsies from 22 women with vulvar lichen sclerosus (LS): 15 patients with early and 7 with the late stage of the disease,
were evaluated. Five women with vulvar squamous cell carcinoma (SCC) were also examined. The control group consisted of 9
women who underwent plastic surgery of the vulvar region. Immunohistochemical staining was performed on formalin-fixed paraffin-embedded
tissues samples using antihuman CD1a antibody (NCL-CD1a-235, Novocastra).
Results: Increased numbers of LC stainings were present in early LS, whereas decreased numbers of these cells were present in late
LS and in SCC compared with the control group.
Conclusions: This study showed that dysregulation of the SIS may lead to suppression of LCs in the vulvar epithelium and may be one of
the reasons for a higher tendency for carcinogenesis in the vulvar region. |
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Keywords: | lichen sclerosus vulva Langerhans cells squamous cell carcinoma |
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