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| 柯萨奇病毒心肌病动物模型研究 | |
| 引用本文： | 聂宏刚,杜秀敏,张烁,张丽丽,李天发,关振中,藤显娥,聂运升. 柯萨奇病毒心肌病动物模型研究[J]. 黑龙江医学, 2011, 35(11): 801-803. DOI: 10.3969/j.issn.1004-5775.2011.11.001 |
| 作者姓名： | 聂宏刚 杜秀敏 张烁 张丽丽 李天发 关振中 藤显娥 聂运升 |
| 作者单位： | 1. 哈尔滨医科大学附属第二医院心内科,黑龙江,哈尔滨,150086 2. 海南医学院附属医院心内科,海南,海口,521000 3. 黑龙江中医药大学附属第一医院,黑龙江,哈尔滨,150040 |
| 基金项目： | 黑龙江省科技厅攻关项目(GCO2C133); 黑龙江省教育厅重点项目115111211; 2011黑龙江省卫生厅科研项目 |
| 摘 要： | 目的 研究反复增量柯萨奇病毒B3m(CVB3m)感染对小鼠心肌的影响,建立病毒性心肌病动物模型.方法 80只3~4周龄雄性Balb/c小鼠,随机分为心肌病组、单次感染组和正常对照组,于首次感染病毒后第120 d处死小鼠,应用阻抗微分法测定心输出量,病理及组织化学技术分析心肌病理损伤和胶原系统改变,计算胶原容积分数.结果... |
| 关 键 词： | 柯萨奇病毒B3 病毒性心肌病 心室重构 |
Animal Model Research on CVB Cardiomyopathy |
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| NIE Hong-gang,DU Xiu-min,ZHANG Shuo,et al.. Animal Model Research on CVB Cardiomyopathy[J]. Heilongjiang Medical Journal, 2011, 35(11): 801-803. DOI: 10.3969/j.issn.1004-5775.2011.11.001 | |
| Authors: | NIE Hong-gang DU Xiu-min ZHANG Shuo et al. |
| Affiliation: | NIE Hong-gang,DU Xiu-min,ZHANG Shuo,et al.(Department of Cardiology,the Second Affiliated Hospital of Harbin Medical University,Harbin 150086,CHINA) |
| Abstract: | Objective To study the influence of myocardium by repetitive increased CVB3m infection and establish virus cardiomyopathy model.Methods 80 male 3~4 week Balb/c mouse were divided cardiomyopathy group,single infected group and control group randomly.The mice were sacrificed on 120 days post first infection.Impedance differentiation was used to calculate cardiac output(CO).The changes of myocardial pathology and collagen were used pathology,histochemistry technique.And the collagen volume fraction was counted... |
| Keywords: | Coxsackievirus B3(CVB3) Viral cardiomyopathy Ventricular remodeling |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |