Subtyping of MRSA isolates belonging to a widely disseminated clonal group by polymorphism of the dru sequences in mec-associated DNA |
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Authors: | Witte W Werner G Cuny C |
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Affiliation: | Robert Koch Institute, Wernigerode Branch, Germany. wittew@rki.de |
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Abstract: | During the past 7 years the "Berlin epidemic MRSA" has spread throughout whole Germany. SmaI macrorestriction patterns of this clonal group are rather stable as are the length polymorphisms at the 3' end of the coagulase gene and the x-region of spa. However, the dru region (direct repeat units) of mec-associated DNA exhibits a length polymorphism due to deletion of one or more direct repeat units. Five different subclones could be discriminated by dru region length polymorphism. Location of deletions and of a few point mutations allow a delineation of these subclones. |
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Keywords: | MRSA molecular typing Wolfgang Witte, Robert Koch Institute, Wernigerode Branch, Burgstra=A7e 37, D-38855 Wernigerode, Germany, Phone: +49 3943 679 246, Fax: +49 3943 679 207, |
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