| 2型糖尿病易患基因在胰岛素分泌中的作用 |
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| 引用本文： | 杨海莲,刘宁生.2型糖尿病易患基因在胰岛素分泌中的作用[J].医学综述,2014(3):385-388. |
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| 作者姓名： | 杨海莲 刘宁生 |
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| 作者单位： | [1]宁波大学医学院,宁波315211 [2]南京医科大学病理教研室／卫生部抗体技术重点实验室,南京210029 |
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| 基金项目： | 浙江省自然科学基金（Y2111021）;宁波社会发展科研项目（2011C50011） |
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| 摘 要： | 2型糖尿病是由胰岛素抵抗及β细胞分泌缺陷引起的,遗传因素在2型糖尿病的发生、发展中发挥着重要的作用。目前国内外已报道了多个与2型糖尿病相关的易患基因,该文就胰岛β细胞中高表达且对2型糖尿病致病贡献较高的12个易患基因在参与胰岛素合成,胰岛β细胞敏感性及β细胞内胰岛素运输方面进行综述,并对基因突变应用于2型糖尿病的预防和治疗作简单介绍。
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| 关 键 词： | 基因突变 2型糖尿病 胰岛素分泌 早期筛查 |
Effects of T2D Susceptibility Gene on Insulin Secretion |
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| Institution: | YANG Hai-lian ,LIU Ning-sheng ( 1. Ningbo University School of Medicine, Ningbo 315211, China ; 2. Department of Pathology, Nanjing Medical University/ Key Lab of Antibody Technique of Ministry of Health, Nanjing 210029, China ) |
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| Abstract: | Type 2 diabetes mellitus （T2DM）is caused by insulin resistance and 13cell secrection deficiency. The genetic factors play an important role in the occurrence and development of this disease and there are many variants have been found and reported in domestic and foreign research field. This review summarizes these 12 T2DM risk loci linked to insulin synthesis, beta cells sensitivity or insulin transport. Genetic suscep- tibility testing use for preventing and treating T2D is also mentioned. |
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| Keywords: | Gene variants Type 2 diabetes Insulin-secretory Early screening |
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