| 托吡酯治疗小儿癫痫 |
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| 引用本文： | 刘智胜,杨立志,王芳琳,王慧燕,胡家胜,吴革菲.托吡酯治疗小儿癫痫[J].中国新药与临床杂志,2001,20(6):452-454. |
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| 作者姓名： | 刘智胜 杨立志 王芳琳 王慧燕 胡家胜 吴革菲 |
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| 作者单位： | 武汉市儿童医院神经内科 |
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| 摘 要： | 目的 :评价托吡酯治疗小儿癫痫的疗效和安全性。方法 :3 1例癫痫病儿 (男性 2 1例 ,女性 10例 ,年龄 6a±s 4a)口服托吡酯 ,起始剂量为 1～ 2mg·kg- 1·d- 1,qd ;目标剂量为 4～ 10mg·kg- 1·d- 1,bid。随访时间为 3～ 8mo。结果 :托吡酯总有效率为 69% ,单药治疗与添加治疗的疗效比较差异无显著意义 (P >0 .0 5 ) ,其不良反应较轻。结论 :托吡酯对于小儿癫痫有较好的疗效 ,单药与添加治疗的疗效近似 ,病儿对其有较好的耐受性。
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| 关 键 词： | 托吡酯 儿童 癫痫 药物疗法 |
| 文章编号： | 1007-7669(2001)06-0452-03 |
Topiramate in treatment of children with epilepsy |
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| LIU Zhi Sheng,YANG Li Zhi,WANG Fang Lin,WANG Hui Yan,HU Jia Sheng,WU Ge Fei.Topiramate in treatment of children with epilepsy[J].Chinese Journal of New Drugs and Clinical Remedies,2001,20(6):452-454. |
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| Authors: | LIU Zhi Sheng YANG Li Zhi WANG Fang Lin WANG Hui Yan HU Jia Sheng WU Ge Fei |
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| Abstract: | AIM: To evaluate the effect and safety of topiramate. METHODS: Thirty one children (M 21, F 10; age 6 a± s 4 a) with epilepsy were treated with topiramate. The onset dosage of topiramate (Topamax) was 1-2 mg·kg -1 ·d -1 , po , qd, and the objective dosage was 4-10 mg·kg -1 ·d -1 , bid. The follow up period was 3-8 mo. RESULTS: The total effective rate of topiramate was 69 % and its adverse reaction was minor in the treatment of children with epilepsy. The total effective rate of monotherapy of topiramate showed no significant difference as compared with adjunctive therapy ( P > 0.05). CONCLUSION: The topiramate is effective in monotherapy and adjunctive therapy, and well tolerated for epilepsy in children. |
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| Keywords: | topiramate child epilepsy drug therapy |
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