Protective effect of trapidil on long-term histologic damage in a rat model of testicular ischemia-reperfusion injury |
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Authors: | Murat Bozlu Deniz Acar Selahittin Cayan Savas Aktas Ahmet Tunckiran |
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Institution: | (1) Department of Urology, University of Mersin School of Medicine, Zeytinlibahce Caddesi, 33079 Mersin, Turkey;(2) Department of Histology/Embryology, University of Mersin School of Medicine, Mersin, Turkey |
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Abstract: | Objectives Trapidil is an antianginal compound with a broad spectrum of pharmacological activities. In recent years, it has been used
successfully to decrease ischemia-reperfusion injury in several organ systems. We evaluated the effect of trapidil on the
long-term histologic damage in testicular ischemia-reperfusion injury.
Methods Adult male Wistar rats were divided into three groups of six rats each. One group underwent 2 h of testicular torsion; one
received pretreatment with trapidil before detorsion; and one group underwent sham operation. All rats underwent bilateral
orchiectomy 60 days after the experiment. The mean seminiferous tubular diameter, germinal epithelial cell thickness, and
mean testicular biopsy score were determined by histological examination of each testis.
Results Testicular torsion–detorsion caused a significant decrease in the mean seminiferous tubular diameter, germinal epithelial
cell thickness, and mean testicular biopsy score in the ipsilateral testes, but not in the contralateral testes. The animals
treated with trapidil had a significant increase in these histological parameters as compared to the torsion–detorsion group.
Conclusion Trapidil administration before reperfusion may have the potential to decrease the long-term histologic damage that occurs
after experimental testicular torsion. Trapidil is used as an antianginal drug and additional clinical studies are required
to elucidate the protective role of trapidil in patients with testicular torsion. |
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Keywords: | Testis Reperfusion injury Trapidil Rats |
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